Glutethimide
Aliases: Glimid, Doriden, Noxyron, Elrodorm
Summary
Is a hypnotic sedative that was introduced in 1954, as a "safe" alternative to barbiturates to treat insomnia. Anecdotally long term use has had effects similar to withdrawal, while still on a stable dose of the drug.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 250mg | 500mg | 750mg | 750mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 30-45 min | 2-8 hrs | 2.5-8.8 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
5.4
Moderate+
5/10
Strong euphoria with mild sedation and itching/nausea
Euphoria / Warmth
×3
9
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
0
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
4
nausea
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
Negative
- Motor impairment
- Increased heart rate
- Nausea
- Respiratory depression
- Vasoconstriction
- Teeth grinding
- Sedation
Positive
- Reduced anxiety
- Cognitive euphoria
- Euphoria
- Anxiety suppression
Negative
- Compulsive redosing
- Anxiety
- Dizziness
- Thought deceleration
- Amnesia
- Time distortion
Positive
- Increased music appreciation
- Increased libido
- Tactile enhancement
- Color enhancement
Negative
- Disinhibition
- Light sensitivity
- Dehydration
- Appetite suppression
- Double vision
- Dulled perception
Combinations
Glutethimide's nerd page
Pharmacology, chemical data, effect profiles, and more
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