Grayanotoxin
Summary
Grayanotoxins are a group of toxic diterpenes found in the ericacaeae family of plants . More than 25 grayanotoxin isoforms have been isolated from rhododendron, though grayanotoxin I and grayanotoxin III are considered to be the most responsible for the toxic pharmacological effects of grayanotoxin-containing plants. Grayanotoxin I, as well as grayanotoxin III, act as agonists of voltage-gated sodium channels.
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Tolerance Decay
Full tolerance
3d
Half tolerance
8d
Baseline
~14d
Effects
Positive
- Physical euphoria
- Muscle relaxation
- Anxiolytic
Negative
- Motor impairment
- Nausea
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Itchiness
Positive
- Reduced anxiety
- Anxiety suppression
- Cognitive euphoria
- Euphoria
Negative
- Dizziness
- Compulsive redosing
- Amnesia
- Thought deceleration
- Motor control loss
- Constipation
Positive
- Increased music appreciation
- Increased libido
Negative
- Disinhibition
- Appetite suppression
- Dehydration
- Light sensitivity
- Double vision
- Acuity suppression
- Dulled perception
- Internal hallucinations
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