Grayanotoxin
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- no dose data
- PubChem toxicity data
- 2 corroborating sources
- no dose data
- PubChem toxicity data
Summary
Grayanotoxins are a group of toxic diterpenes found in the ericacaeae family of plants . More than 25 grayanotoxin isoforms have been isolated from rhododendron, though grayanotoxin I and grayanotoxin III are considered to be the most responsible for the toxic pharmacological effects of grayanotoxin-containing plants. Grayanotoxin I, as well as grayanotoxin III, act as agonists of voltage-gated sodium channels.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Physical euphoria
- Muscle relaxation
- Anxiolytic
- Motor impairment
- Nausea
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Itchiness
- Reduced anxiety
- Anxiety suppression
- Cognitive euphoria
- Euphoria
- Dizziness
- Compulsive redosing
- Amnesia
- Thought deceleration
- Motor control loss
- Constipation
- Increased music appreciation
- Increased libido
- Disinhibition
- Appetite suppression
- Dehydration
- Light sensitivity
- Double vision
- Acuity suppression
- Dulled perception
- Internal hallucinations
Helpful Links
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