Hydromorphine Stats & Data
PubChem
MW287.35
FormulaC17H21NO3
LogP1.8
IUPAC3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
InChIKey
IJVCSMSMFSCRME-UHFFFAOYSA-N
Chemical Class
medicine
Psychoactive Class
Depressant
Pharmacology
DrugBankMetabolism
Paramorfan is a known human metabolite of dihydrocodeine.
Effect Profile
Curated
Opioid
5.1
Strong euphoria with moderate itching/nausea, mild sedation
Euphoria / Warmth×3
9
Analgesia×2
0
Sedation / Relaxation×1
5
Itching / Nausea×1
6
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.