Ibotenic acid
Aliases: Ibotenate, Premuscimol
Categories
Summary
Ibotenic acid is a powerful neurotoxin and the primary psychoactive constituent of Amanita muscaria. It acts as a prodrug to muscimol, which produces most of the sedative and GABAergic effects. Upon ingestion, a portion of ibotenic acid is decarboxylated to muscimol in the body, while substantial amounts are excreted unchanged in urine. Ibotenic acid itself acts as a glutamate receptor agonist and may have stimulant-like properties distinct from muscimol's depressant effects. The compound is used extensively in neuroscience research as a brain-lesioning agent due to its excitotoxic properties.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 1-2 hrs | 2-4 hrs | 2-4 hrs | 24 hrs |
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Effects
Positive
- Muscle relaxation
- Pain relief
Negative
- Ataxia
- Nausea
- Muscle twitching
- Motor impairment
- Sedation
- Sleepiness
- Muscle twitches
- Increased salivation
Positive
- Euphoria
- Cognitive euphoria
- Dream potentiation
Negative
- Confusion
- Delirium
- Drowsiness
- Disorientation
- Retrograde amnesia
- Dream-like state
- Consciousness disconnection
Positive
- Colour shifting
- Increased music appreciation
Negative
- Visual distortions
- Auditory distortions
- Sensations of floating
- Dulled perception
- Drifting
- External hallucination
- Internal hallucination
- Spontaneous physical sensations