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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Deliriants can cause frightening, uncontrollable hallucinations and dangerous behavior. Medical emergencies are common at higher doses.

    Ibotenic acid

    Aliases: Ibotenate, Premuscimol

    Depressant Dissociative Deliriant Research-chemical

    Summary TheDrug.Wiki PsychonautWiki

    Ibotenic acid is a powerful neurotoxin and the primary psychoactive constituent of Amanita muscaria. It acts as a prodrug to muscimol, which produces most of the sedative and GABAergic effects. Upon ingestion, a portion of ibotenic acid is decarboxylated to muscimol in the body, while substantial amounts are excreted unchanged in urine.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 0.5-2 hrs 1-2 hrs 2-4 hrs 2-4 hrs 24-24 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 3.1
    Light+ 3/10

    Low dissociative depth, mania, and motor impairment

    Dissociative Depth ×3
    2
    consciousness disconnection
    ⚠ Mania / Compulsion ×1
    2
    euphoria
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    2
    ataxia
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Ibotenic acid
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 0h Half tolerance 1d Baseline ~7d

    No formal human data on tolerance kinetics for ibotenic acid or muscimol; repeated frequent use is uncommon due to sedation and adverse effects. Anecdotal reports suggest minimal cross-tolerance with muscimol and return to baseline within days to a week; confidence low.

    Cross-Tolerances

    Muscimol
    30%

    Effects TheDrug.Wiki

    Positive
    • Muscle relaxation
    • Pain relief
    Negative
    • Ataxia
    • Nausea
    • Muscle twitching
    • Motor impairment
    Neutral
    • Sedation
    • Sleepiness
    • Muscle twitches
    • Increased salivation
    Positive
    • Euphoria
    • Cognitive euphoria
    • Dream potentiation
    Negative
    • Confusion
    • Delirium
    • Drowsiness
    • Disorientation
    • Retrograde amnesia
    Neutral
    • Dream-like state
    • Consciousness disconnection
    Positive
    • Colour shifting
    • Increased music appreciation
    Neutral
    • Visual distortions
    • Auditory distortions
    • Sensations of floating
    • Dulled perception
    • Drifting
    • External hallucination
    • Internal hallucination
    • Spontaneous physical sensations

    Combinations TripSit

    Ibotenic acid's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki