Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Deliriants can cause frightening, uncontrollable hallucinations and dangerous behavior. Medical emergencies are common at higher doses.

    Ibotenic acid Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Ibotenate, Premuscimol

    Depressant Dissociative Deliriant Research-chemical

    Summary dose.wiki PsychonautWiki

    Ibotenic acid is a powerful neurotoxin and the primary psychoactive constituent of Amanita muscaria. It acts as a prodrug to muscimol, which produces most of the sedative and GABAergic effects. Upon ingestion, a portion of ibotenic acid is decarboxylated to muscimol in the body, while substantial amounts are excreted unchanged in urine.

    Dose Information dose.wiki Drugs.Wiki

    No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.

    Dose basis. These values refer to pure ibotenic acid, not whole Amanita material. Evidence indicates ibotenic acid is substantially less potent than muscimol and contributes more adverse effects; most recreational Amanita effects are from muscimol after decarboxylation. Due to excitotoxicity concerns and high variability in mushroom content, targeting ibotenic acid doses is not recommended. Prefer preparations that decarboxylate ibotenic acid to muscimol. Values below are collated from pharmacological summaries and user-facing literature; they are not safety guarantees. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 30-50mg 50-100mg 100-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 0.5-2 hrs 1-2 hrs 2-4 hrs 2-4 hrs 24 hrs 5.5-12 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 3.1
    Light+ 3/10

    Low dissociative depth, mania, and motor impairment

    Dissociative Depth ×3
    2
    consciousness disconnection
    ⚠ Mania / Compulsion ×1
    2
    euphoria
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    2
    ataxia
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Ibotenic acid there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Ibotenic acid (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Ibotenic acid
    Unit
    mg
    Description 
    Ibotenic acid
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 30 · light 30-50 · common 50-100 · strong 100-150 · heavy 150+

Oral duration: onset 0.5-2h · come-up 1-2h · peak 2-4h · offset 2-4h · total 5.5-12h · after-effects 24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 75 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset days to weeks depending on duration of use

    Tolerance Decay

    Half tolerance 3d Baseline ~14d

    No formal human data on tolerance kinetics for ibotenic acid or muscimol; repeated frequent use is uncommon due to sedation and adverse effects. Anecdotal reports suggest minimal cross-tolerance with muscimol and return to baseline within days to a week; confidence low.

    Cross-Tolerances

    Muscimol
    30%

    Effects dose.wiki

    Positive
    • Muscle relaxation
    • Pain relief
    Negative
    • Ataxia
    • Nausea
    • Muscle twitching
    • Motor impairment
    Neutral
    • Sedation
    • Sleepiness
    • Muscle twitches
    • Increased salivation
    Positive
    • Euphoria
    • Cognitive euphoria
    • Dream potentiation
    Negative
    • Confusion
    • Delirium
    • Drowsiness
    • Disorientation
    • Retrograde amnesia
    Neutral
    • Dream-like state
    • Consciousness disconnection
    Positive
    • Colour shifting
    • Increased music appreciation
    Neutral
    • Visual distortions
    • Auditory distortions
    • Sensations of floating
    • Dulled perception
    • Drifting
    • External hallucination
    • Internal hallucination
    • Spontaneous physical sensations

    Combinations

    Cross-Check Ibotenic acid with another substance

    Ibotenic acid's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki