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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Deliriants can cause frightening, uncontrollable hallucinations and dangerous behavior. Medical emergencies are common at higher doses.

    Ibotenic acid Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Ibotenate, Premuscimol

    Depressant Dissociative Deliriant Research-chemical

    Summary TheDrug.Wiki PsychonautWiki

    Ibotenic acid is a powerful neurotoxin and the primary psychoactive constituent of Amanita muscaria. It acts as a prodrug to muscimol, which produces most of the sedative and GABAergic effects. Upon ingestion, a portion of ibotenic acid is decarboxylated to muscimol in the body, while substantial amounts are excreted unchanged in urine.

    Dose Information TheDrug.Wiki

    No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.

    ROA Light Common Strong Heavy
    Oral 30-50mg 50-100mg 100-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 0.5-3 hrs 2-4 hrs 2-4 hrs 24 hrs 6-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 3.1
    Light+ 3/10

    Low dissociative depth, mania, and motor impairment

    Dissociative Depth ×3
    2
    consciousness disconnection
    ⚠ Mania / Compulsion ×1
    2
    euphoria
    Insight / Novel Thought ×2
    0
    ⚠ Motor / Sensory Impairment ×1
    2
    ataxia
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Ibotenic acid
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use (serotonergic psychedelic)
    Reset 7–14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~14d

    No formal human data on tolerance kinetics for ibotenic acid or muscimol; repeated frequent use is uncommon due to sedation and adverse effects. Anecdotal reports suggest minimal cross-tolerance with muscimol and return to baseline within days to a week; confidence low.

    Cross-Tolerances

    Muscimol
    30%

    Effects TheDrug.Wiki

    Positive
    • Muscle relaxation
    • Pain relief
    Negative
    • Ataxia
    • Nausea
    • Muscle twitching
    • Motor impairment
    Neutral
    • Sedation
    • Sleepiness
    • Muscle twitches
    • Increased salivation
    Positive
    • Euphoria
    • Cognitive euphoria
    • Dream potentiation
    Negative
    • Confusion
    • Delirium
    • Drowsiness
    • Disorientation
    • Retrograde amnesia
    Neutral
    • Dream-like state
    • Consciousness disconnection
    Positive
    • Colour shifting
    • Increased music appreciation
    Neutral
    • Visual distortions
    • Auditory distortions
    • Sensations of floating
    • Dulled perception
    • Drifting
    • External hallucination
    • Internal hallucination
    • Spontaneous physical sensations

    Combinations TripSit

    Cross-Check Ibotenic acid with another substance

    Ibotenic acid's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki