Isophenidine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- classified Research-chemical
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- classified Research-chemical
Aliases: NPDPA, Isopropylphenidine, N-isopropyl-1,2-diphenylethylamine, NSC 34569
Summary
Isophenidine (NPDPA) is a dissociative research chemical of the 1,2-diarylethylamine (phenidine) family, acting as an NMDA-receptor antagonist with possible weak dopaminergic/noradrenergic reuptake inhibition. Human data are extremely sparse — most dose, timing and effect information comes from a handful of anecdotal self-reports rather than clinical studies. Identity confusion is a notable risk: it has been mis-sold as or confused with isopropylphenidate. Treat dose figures as approximate and start low.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 75-125mg | 125-200mg | 200-250mg | 250mg+ |
| Insufflated | 60-100mg | 100-150mg | 150-200mg | 200mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 30-60 min | 1-3 hrs | 2-3 hrs | 3-6 hrs |
| Insufflated | 5-15 min | 15-60 min | 0.5-2 hrs | 1-3 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild dissociative depth with low mania and motor impairment
Tolerance
Effects
- Mild stimulation
- Numbness
- Dizziness
- Altered body boundaries
- Euphoria
- Derealization
- Depersonalization
- Confusion at higher doses
- Dissociation
- Cognitive lucidity at lower doses
- Sensory enhancement
- Visual patterning
Helpful Links
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