First Beautiful Foray with Isoproscaline Substance: Isoproscaline, 45mg (weighed out) Set & Setting: My condominium on a Saturday evening. Feeling generally positive and good.
Isoproscaline
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: Ip
Summary
A analogue of mescaline, and more closely related to proscaline.
Perspectives
“Starts slowly. I develop some queasiness, turning into nausea. Feels good to lie down and let go, but the uneasiness remains. Just beginning to break through in 2 hours. But the occasional sense of relief, the breaking into the open, were transient as new sources of discomfort were always being dredged up. Then for some reason I chose to dance. Letting go to dancing, a marvelous ecstatic experience, flowing with and being the energy, body feeling completely free. Noticing how this letting go got one completely out of the feeling of unease, as though attention simply needs to be put elsewhere. Comedown was very slow, gentle, euphoric; a very signicant experience. Sleep that night was impossible, but felt good to simply release to the feelings. Keeping mind still, no thinking, just allowing feelings to go where they wished, became more and more ecstatic. Tremendous feeling of confidence in life and the life process. Complete sense of resolution.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 40-50mg | 50-60mg | 60-80mg | 80mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 1-3 hrs | 10-20 hrs | 10-20 hrs |
Effect Profile
4 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.1
Light+
3/10
Mild visuals with low body load and headspace
Visual Intensity
×3
4
color enhancement
brightened colour
visual distortions
Headspace Depth
×3
2
confusion
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
3
muscle tension
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7โ14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 4 Erowid experience reports
Positive Effects 5
Color Enhancement
100.0%
70%
Empathy
75.0%
70%
Music Enhancement
75.0%
70%
Stimulation
75.0%
70%
Euphoria
75.0%
70%
Adverse Effects 2
Nausea
75.0%
70%
Confusion
75.0%
70%
Combinations
Cross-Check Isoproscaline with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 4 reports 1 positive 3 neutral visit
1. Subject Information 1.1 Usage Details Substance: Isoproscaline Date of use: 2025/9/26 Dose: ~80 mg Purity: 97% (HPLC) Route of administration: Mostly oral, with a smaller portion taken intranasally 1.2 User Information Age: 22 Sex (Assigned at Birth): Male Height: 176 cm Weight: 49 kg Background / medical history: H...
First Trial With Isoproscaline Isoproscaline*HCl ย 4-isopropoxy-3,5-dimethoxyphenethylamine hydrochloride Dosage: 80 mg Set: starting at a train station on the way home, then at home, mostly in front of computer, listening to music. Setting: currently difficult situation in life. Earlier, some conflict with my dad.
More than 20 years ago perusing the second section of Shulgin's PIHKAL my eyes fell on #92; beguiled by the two glowing accounts furnished by way of illustrating the 'color and complexity of IP" and above all by Sasha's declaration that it has "proven to be a completely fascinating phenethylamine" a mild, if enduring o...
PiHKAL / TiHKAL
PiHKAL #92: IP
“Starts slowly. I develop some queasiness, turning into nausea. Feels good to lie down and let go, but the uneasiness remains. Just beginning to break through in 2 hours. But the occasional sense of relief, the breaking into the open, were transient as new sources of discomfort were always being dredged up. Then for some reason I chose to dance. Letting go to dancing, a marvelous ecstatic experience, flowing with and being the energy, body feeling completely free. Noticing how this letting go got one completely out of the feeling of unease, as though attention simply needs to be put elsewhere. Comedown was very slow, gentle, euphoric; a very signicant experience. Sleep that night was impossible, but felt good to simply release to the feelings. Keeping mind still, no thinking, just allowing feelings to go where they wished, became more and more ecstatic. Tremendous feeling of confidence in life and the life process. Complete sense of resolution.”
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