Isotonitazepyne
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Npi, Iso-pyne
Summary
Isotonitazepyne (also known as Iso-pyne) is a synthetic opioid of the benzimidazole class, encountered as a research chemical and acting as a central nervous system depressant. It is approximately 1000 times more potent than morphine in vitro, with active doses in the microgram range, making volumetric dosing or pre-measured nasal spray formulations essential. Counterfeit pharmaceutical pills marketed as oxycodone and containing 3-4 mg per pill have caused multiple fatalities in Europe.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. This is a microgram-active opioid: a normal milligram scale cannot weigh a dose of it accurately, and a weighing error here is measured in lethal multiples rather than percentages. Volumetric dosing is the only defensible method, and batch-to-batch potency in the unregulated supply varies enormously. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 25-100ยตg | 100-300ยตg | 300-600ยตg | 600ยตg+ |
| Oral | 50-150ยตg | 150-400ยตg | 400-800ยตg | 800ยตg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 5-15 min | 5-10 min | 30-90 min | 1-2 hrs | 1.66-3.92 hrs |
| Oral | 15-30 min | 10-20 min | 30-90 min | 1-2 hrs | 1.92-4.33 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria, itching/nausea, and pain relief with mild sedation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Isotonitazepyne there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Isotonitazepyne Source: SubstanceSearch (substancesearch.com) Insufflated dose (ยตg): threshold 25 ยท light 25-100 ยท common 100-300 ยท strong 300-600 ยท heavy 600+ Oral dose (ยตg): threshold 50 ยท light 50-150 ยท common 150-400 ยท strong 400-800 ยท heavy 800+ Insufflated duration: onset 5-15m ยท come-up 5-10m ยท peak 0.5-1.5h ยท offset 1-2h ยท total 1.66-3.92h ยท after-effects 1-3h Oral duration: onset 15-30m ยท come-up 10-20m ยท peak 0.5-1.5h ยท offset 1-2h ยท total 1.92-4.33h ยท after-effects 1-3h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 200 ยตg (Insufflated).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Opioid tolerance can escalate quickly with shortโacting, highโefficacy ฮผโagonists (general opioid HR guidance). Do not base doses on othersโ reportsโinterโindividual tolerance differences are large and overdose margin is narrow.
Cross-Tolerances
Effects
- Physical euphoria
- Pain relief
- Muscle relaxation
- Analgesia
- Respiratory depression
- Nausea
- Itching
- Sedation
- Itchiness
- Pupil constriction
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Euphoria
- Motivation suppression
- Compulsive redosing
- Constipation
- Anxiety
- Warmth
- Increased music appreciation
- Increased libido
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Internal hallucination
- Dulled perception
- Warm flush
Combinations
Cross-Check Isotonitazepyne with another substanceHelpful Links
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