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    Disclaimer
    ☠ This substance has been associated with serious adverse events including fatalities. Use extreme caution.
    ☒ This substance has an extremely narrow safety margin. Small dosing errors can lead to life-threatening effects.
    ☠ Nitazene-class opioids are extremely potent, often exceeding fentanyl in strength. Even trace amounts can be fatal. Naloxone should always be on hand.
    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Isotonitazepyne

    Aliases: Npi, Iso-pyne

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Isotonitazepyne is approximately 1000 times more potent than morphine in vitro. Active doses are in the microgram range; volumetric dosing or pre-measured nasal spray formulations are essential. Counterfeit pharmaceutical pills (marketed as oxycodone) containing 3-4 mg per pill have caused multiple fatalities in Europe.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Intranasal 5-15 min 5-10 min 30-90 min 1-2 hrs 1-3 hrs
    Oral 15-30 min 10-20 min 30-90 min 1-2 hrs 1-3 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.3
    Strong+ 7/10

    Strong euphoria, itching/nausea, and pain relief with mild sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria warmth
    Analgesia ×2
    8
    pain relief analgesia
    Sedation / Relaxation ×1
    5
    sedation muscle relaxation
    ⚠ Itching / Nausea ×1
    10
    itching nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Isotonitazepyne
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks β€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Opioid tolerance can escalate quickly with short‑acting, high‑efficacy μ‑agonists (general opioid HR guidance). Do not base doses on others’ reportsβ€”inter‑individual tolerance differences are large and overdose margin is narrow.

    Cross-Tolerances

    Other benzimidazole opioids (nitazenes)
    70%
    Fentanyl analogues
    50%

    Effects TheDrug.Wiki

    Positive
    • Physical euphoria
    • Pain relief
    • Muscle relaxation
    • Analgesia
    Negative
    • Respiratory depression
    • Nausea
    • Itching
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Reduced anxiety
    • Wakefulness
    • Motivation enhancement
    • Euphoria
    Negative
    • Motivation suppression
    • Compulsive redosing
    • Constipation
    • Anxiety
    Positive
    • Warmth
    • Increased music appreciation
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Internal hallucination
    • Dulled perception
    • Warm flush

    Combinations TripSit

    Isotonitazepyne's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    πŸ“˜ Experience Reports πŸ“– TheDrug.Wiki πŸ“– PsychonautWiki