Isotonitazepyne
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Npi, Iso-pyne
Summary
Isotonitazepyne (also known as Iso-pyne) is a synthetic opioid of the benzimidazole class, encountered as a research chemical and acting as a central nervous system depressant. It is approximately 1000 times more potent than morphine in vitro, with active doses in the microgram range, making volumetric dosing or pre-measured nasal spray formulations essential. Counterfeit pharmaceutical pills marketed as oxycodone and containing 3-4 mg per pill have caused multiple fatalities in Europe.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 25-100Β΅g | 100-300Β΅g | 300-600Β΅g | 600Β΅g+ |
| Oral | 50-150Β΅g | 150-400Β΅g | 400-800Β΅g | 800Β΅g+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Insufflated | - | 30-90 min | 1-2 hrs | 3-5 hrs |
| Oral | 15-30 min | 30-90 min | 1-2 hrs | 3-5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria, itching/nausea, and pain relief with mild sedation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Opioid tolerance can escalate quickly with shortβacting, highβefficacy ΞΌβagonists (general opioid HR guidance). Do not base doses on othersβ reportsβinterβindividual tolerance differences are large and overdose margin is narrow.
Cross-Tolerances
Effects
- Physical euphoria
- Pain relief
- Muscle relaxation
- Analgesia
- Respiratory depression
- Nausea
- Itching
- Sedation
- Itchiness
- Pupil constriction
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Euphoria
- Motivation suppression
- Compulsive redosing
- Constipation
- Anxiety
- Warmth
- Increased music appreciation
- Increased libido
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Internal hallucination
- Dulled perception
- Warm flush
Combinations
Cross-Check Isotonitazepyne with another substanceHelpful Links
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