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    JWH-073 molecular structure

    JWH-073 Stats & Data

    Spice
    NPS DataHub
    MW327.43
    FormulaC23H21NO
    CAS208987-48-8
    IUPACNaphthalen-1-yl-(1-butylindol-3-yl)methanone
    SMILESCCCCn1cc(C(=O)c2cccc3ccccc23)c2ccccc12
    InChIKeyVCHHHSMPMLNVGS-UHFFFAOYSA-N
    Cannabinoids; 2020/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2021/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen; 2022/2.1 Von Indol Pyrazol und 4-Chinolon abgeleitete Verbindungen
    Chemical Class Cannabinoid

    Pharmacology

    DrugBank

    Mechanism of Action

    /Synthetic cannabinoid/ agonistic activity on the CB1 receptor is responsible for elevating mood and inducing a feeling of well-being. Some /synthetic cannabinoid/ users have reported effects similar to or even stronger than those obtained by smoking cannabis, such as physical relaxation, changes in perception, and mild euphoria.

    Metabolism

    ... The lack or low content of /JWH-018 and JWH-073/ in urine requires detailed identification of their metabolites, which are excreted with urine and are present in blood. Using gas and liquid chromatography-mass spectrometry, /investigators/ identified a series of metabolites in urine samples from humans and rats that were products of the following reactions: (a) mono- and dihydroxylation of the parent compounds with hydroxyl groups located at aromatic and aliphatic residues, (b) carboxylation

    Receptor Profile

    Receptor Actions

    Agonists
    CB1 receptor agonist (full)
    CB2 receptor agonist (full, 5x lower affinity than CB1)

    History & Culture

    JWH-073 derives its name from John W. Huffman, the American organic chemist whose laboratory developed this and numerous other synthetic cannabinoid compounds as part of cannabinoid receptor research. The "JWH" prefix identifies compounds originating from Huffman's work. The compound entered the recreational drug market as a component of herbal smoking blends sold under the "Spice" brand name during the late 2000s. It was reportedly among the first variations from JWH-018 to appear in the original Spice product line. In April 2009, researchers at the University of Freiburg identified JWH-073 in a product deceptively marketed as "Forest Humus" fertilizer, alongside another synthetic cannabinoid. Following Germany's prohibition of JWH-018, testing of seized Spice products in July 2009 revealed that manufacturers had reformulated their blends to contain the then-unscheduled JWH-073 as a substitute compound. The authentic Spice brand eventually disappeared from the market before the proliferation of more potent synthetic cannabinoids under numerous other product names and labels. However, its cultural impact endured, with the term "Spice" becoming widely adopted as a generic descriptor for synthetic cannabinoid products regardless of their actual composition—a misappropriation of the original brand name that persists in colloquial usage.

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 3d Half tolerance 21d Baseline ~28d

    Experience Report Analysis

    Erowid
    34 Reports
    2008–2017 Date Range
    31 With Age Data
    26 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 34 experience reports (34 Erowid)

    34 Reports
    26 Effects Detected
    10 Positive
    9 Adverse
    7 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 10

    Focus Enhancement 38.2% 70%
    Euphoria 32.4% 70%
    Body High 32.4% 70%
    Color Enhancement 29.4% 70%
    Empathy 29.4% 70%
    Music Enhancement 29.4% 70%
    Stimulation 23.5% 70%
    Introspection 14.7% 70%
    Tactile Enhancement 14.7% 70%
    Pain Relief 8.8% 70%

    Adverse Effects 9

    Anxiety 67.6% 70%
    Confusion 41.2% 70%
    Nausea 29.4% 70%
    Memory Suppression 23.5% 70%
    Motor Impairment 20.6% 70%
    Increased Heart Rate 17.6% 70%
    Pupil Dilation 8.8% 70%
    Headache 8.8% 70%
    Psychosis 8.8% 70%

    Form / Preparation

    Most common forms and preparations reported

    Legal Status

    Country Status Notes
    Australia Schedule 9 Prohibited substance under the Poisons Standard since July 8, 2011. Schedule 9 classification restricts manufacture, possession, sale, and use except when required for approved medical or scientific research, or for analytical, teaching, or training purposes with authorization from Commonwealth and/or State or Territory Health Authorities.
    Germany Anlage II BtMG Classified under the Betäubungsmittelgesetz (Narcotics Act). Was initially unregulated and appeared as a substitute compound in Spice products following Germany's prohibition of JWH-018 in 2009, before being subsequently controlled.
    New Zealand Banned Sale prohibited as of May 8, 2014.
    Turkey Banned Sale prohibited as of January 7, 2011.
    United States Schedule I Temporarily designated as Schedule I on March 1, 2011 through 76 FR 11075, then permanently classified under Schedule I on July 9, 2012 via Section 1152 of the Food and Drug Administration Safety and Innovation Act.
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