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    K-Opioid receptor agonist Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 1 source
    • no dose data
    • 19 combo interactions documented

    Summary PsychonautWiki

    κ-Opioid receptor agonists are psychoactive drugs, which induce atypical hallucinogenic effects. They bind to the kappa opioid receptors with varying affinities.

    Effect Profile

    class estimate

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • No reports exist for this substance. Its effect list is the one shared by 1 other substance of the same class, so the scores below describe the class, not this compound.
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.5
    Strong 6/10

    Strong visuals with mild headspace, auditory effects, and body load

    Visual Intensity ×3
    10
    color enhancement drifting tracers pattern recognition enhancement visual distortions brightened colour
    Headspace Depth ×3
    4
    introspection time distortion confusion
    Auditory Effects ×1
    4
    auditory distortion
    Body Load / Somatic Effects ×1
    4
    nausea increased heart rate
    Opioid 2.6
    Light+ 3/10

    Mild itching/nausea with low euphoria and sedation

    Euphoria / Warmth ×3
    3
    euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    3
    sedation
    Itching / Nausea ×1
    4
    nausea

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects

    Positive
    • Stimulation
    • Mental/physical stimulation
    Negative
    • Nausea
    • Pupil dilation
    • Increased heart rate
    • Insomnia
    • Restlessness
    Neutral
    • Dilated pupils
    • Decreased appetite
    • Sedation
    Positive
    • Introspection
    • Euphoria
    • Wakefulness
    • Empathy
    • Insight
    • Analysis enhancement
    Negative
    • Anxiety
    • Confusion
    Neutral
    • Time distortion
    • Ego softening
    Positive
    • Color enhancement
    • Increased music appreciation
    • Tracers
    • Tactile enhancement
    • Enhanced tactile sensation
    • Pattern recognition enhancement
    • Brightened colour
    Neutral
    • Visual distortions
    • Drifting
    • Auditory distortion

    Combinations

    Cross-Check K-Opioid receptor agonist with another substance

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