K-Opioid receptor agonist
Summary
κ-Opioid receptor agonists are psychoactive drugs, which induce atypical hallucinogenic effects. They bind to the kappa opioid receptors with varying affinities.
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
6.5
Strong
6/10
Strong visuals with mild headspace, auditory effects, and body load
Visual Intensity
×3
10
color enhancement
drifting
tracers
pattern recognition enhancement
visual distortions
brightened colour
Headspace Depth
×3
4
introspection
time distortion
confusion
Auditory Effects
×1
4
auditory distortion
Body Load / Somatic Effects
×1
4
nausea
increased heart rate
Opioid
2.6
Light+
3/10
Mild itching/nausea with low euphoria and sedation
Euphoria / Warmth
×3
3
euphoria
Analgesia
×2
0
Sedation / Relaxation
×1
3
sedation
Itching / Nausea
×1
4
nausea
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Effects
Positive
- Stimulation
- Mental/physical stimulation
Negative
- Nausea
- Pupil dilation
- Increased heart rate
- Insomnia
- Restlessness
- Dilated pupils
- Decreased appetite
- Sedation
Positive
- Introspection
- Euphoria
- Wakefulness
- Empathy
- Insight
- Analysis enhancement
Negative
- Anxiety
- Confusion
- Time distortion
- Ego softening
Positive
- Color enhancement
- Increased music appreciation
- Tracers
- Tactile enhancement
- Enhanced tactile sensation
- Pattern recognition enhancement
- Brightened colour
- Visual distortions
- Drifting
- Auditory distortion
Combinations
K-Opioid receptor agonist's nerd page
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