Summary
A South African plant containing numerous psychoactive alkaloids, including mesembrine and mesembrenone. The first written account of the substance was in 1662. The pharmacology of these compounds is poorly understood, but they are suspected to be serotonin uptake inhibitors and potentially monoamine releasers. Said to suppress appetite, produce mild euphoria and reduce anxiety.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 10-20mg | 20-50mg | 50-150mg | 150mg+ |
| Oral | 250-500mg | 500-1000mg | 1000-2000mg | 2000mg+ |
| Vapourized | 30-50mg | 50-100mg | 100-250mg | 250mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | After Effects |
|---|---|---|---|
| Insufflated | 5-10 min | 1.0-2.5 hrs | 1.0-8.0 hrs |
| Oral | 30-90 min | 3.0-6.0 hrs | 1.0-8.0 hrs |
| Vapourized | - | 1.5-2.5 hrs | 1.0-8.0 hrs |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
Negative
- Motor impairment
- Increased heart rate
- Nausea
- Respiratory depression
- Vasoconstriction
- Teeth grinding
- Sedation
Positive
- Reduced anxiety
- Cognitive euphoria
- Euphoria
- Anxiety suppression
- Wakefulness
Negative
- Compulsive redosing
- Anxiety
- Dizziness
- Thought deceleration
- Time distortion
Positive
- Increased music appreciation
- Increased libido
- Tactile enhancement
- Color enhancement
Negative
- Disinhibition
- Dehydration
- Appetite suppression
- Light sensitivity
- Double vision
- Dulled perception