Home
    Disclaimer
    ← Back to Ketobemidone
    Ketobemidone molecular structure

    Ketobemidone Stats & Data

    Depressant Opioid
    Kbd
    NPS DataHub
    MW247.34
    FormulaC15H21NO2
    CAS469-79-4
    IUPAC1-[4-(3-Hydroxyphenyl)-1-methyl-4-piperidyl]propan-1-one
    SMILESCCC(=O)C1(CCN(C)CC1)c1cccc(O)c1
    InChIKeyALFGKMXHOUSVAD-UHFFFAOYSA-N
    Chemical Class Opioid
    Psychoactive Class Depressant

    Pharmacology

    DrugBank
    State Solid Absorption 34% (oral), 44% (rectal)

    Description

    Ketobemidone is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide to 60 mg of morphine hydrochloride or sulfate and circa 8 mg of ketobemidone by injection.

    Mechanism of Action

    Ketobemidone (Cliradon, Ketogan, Ketodur, Cymidon, Ketorax, &c.) is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide to 60 mg of morphine hydrochloride or sulfate and circa 8 mg of ketobemidone by injection.

    Metabolism

    Ketobemidone is mainly metabolised by conjugation of the phenolic hydroxyl group, and by N-desmethylation. Only about 13-24% is excreted unchanged after iv. administration.

    Toxicity

    Base: Rat Intravenous LD50: 10 mg/kg; Mouse Intravenous LD50: 14 mg/kg. Hydrochloride salt: Rat Oral LD50: 215 mg/kg; Rat Intravenous LD50: 40 mg/kg

    Indication

    For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures.

    Half-life

    Plasma half-life: 2.42 +/- 0.41 h (m +/- SD). Elimination half-life: 3.27 +/- 0.32 h

    Effect Profile

    Curated + 3 Reports
    Opioid 6.3

    Strong euphoria with moderate itching/nausea, mild pain relief, low sedation

    Euphoria / Warmth×3
    10
    Analgesia×2
    4
    Sedation / Relaxation×1
    3
    Itching / Nausea×1
    7
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Ketobemidone

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Experience Report Analysis

    Erowid
    3 Reports
    2007–2017 Date Range
    2 With Age Data
    2 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 3 experience reports (3 Erowid)

    3 Reports
    2 Effects Detected
    1 Positive
    1 Adverse
    0 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 1

    Euphoria 100.0% 70%

    Adverse Effects 1

    Nausea 100.0% 70%

    Real-World Dose Distribution

    62K Doses

    From 9 individual dose entries

    Oral (n=6)

    Median: 10.0mg 25th: 5.0mg 75th: 18.75mg 90th: 22.5mg

    Form / Preparation

    Most common forms and preparations reported

    Read full reports on Erowid →
    ← Back to Ketobemidone