Lamotrigine
Aliases: Ltg, Lamictal, Subvenite, Lamictal xr, Lamictal odt
Summary
Self-reports cluster around four oral bands: a perceptible threshold cognitive lift at 12.5-25 mg, functional mood balance between 50-150 mg, pronounced but sedating effects at 200-300 mg, and heavy 400 mg+ experiments that many posters later regret. Clinical references corroborate a long half-life (25-33 h) and flag potent pharmacokinetic interactions—valproate can double lamotrigine levels, while carbamazepine or ethinylestradiol can halve them—explaining several adverse-event threads on harm-reduction boards. Titration must start at 25 mg every other day to avoid rash; typical maintenance 100-200 mg divided once or twice daily.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 300mg+(rashrisk↑↑)+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 1-3 hrs | 4-8 hrs | 8-16 hrs |
Tolerance
Tolerance Decay
Lamotrigine is not typically associated with classical tolerance to its antiseizure or mood-stabilizing effects. Dose adjustments are based on clinical response and pharmacokinetic interactions rather than tolerance. Abrupt cessation can precipitate seizures; gradual taper is recommended.
Effects
Aggregated from 31 Erowid experience reports