For a little bit of history, I've been dealing with depression my entire life, and that's what has unfortunately lead me to the situation that I was in. I began smoking weed in middle school, it wasn't until high school that my interest for other drugs began to expand.
Lamotrigine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Ltg, Lamictal, Subvenite, Lamictal xr, Lamictal odt
Summary
Self-reports cluster around four oral bands: a perceptible threshold cognitive lift at 12.5-25 mg, functional mood balance between 50-150 mg, pronounced but sedating effects at 200-300 mg, and heavy 400 mg+ experiments that many posters later regret. Clinical references corroborate a long half-life (25-33 h) and flag potent pharmacokinetic interactions—valproate can double lamotrigine levels, while carbamazepine or ethinylestradiol can halve them—explaining several adverse-event threads on harm-reduction boards. Titration must start at 25 mg every other day to avoid rash; typical maintenance 100-200 mg divided once or twice daily.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-50mg | 50-150mg | 150-300mg | 300mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 1-3 hrs | 4-8 hrs | 8-16 hrs | 12-24 hrs |
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Tolerance Decay
Half tolerance
7d
Baseline
~14d
Lamotrigine is not typically associated with classical tolerance to its antiseizure or mood-stabilizing effects. Dose adjustments are based on clinical response and pharmacokinetic interactions rather than tolerance. Abrupt cessation can precipitate seizures; gradual taper is recommended.
Effects
Aggregated from 31 Erowid experience reports
Positive Effects 11
Anxiety Suppression
61.3%
70%
Stimulation
51.6%
70%
Music Enhancement
35.5%
70%
Euphoria
32.3%
70%
Color Enhancement
25.8%
70%
Empathy
25.8%
70%
Focus Enhancement
19.4%
70%
Sedation
16.1%
70%
Tactile Enhancement
16.1%
70%
Introspection
12.9%
70%
Body High
9.7%
70%
Adverse Effects 5
Confusion
22.6%
70%
Seizure
16.1%
70%
Memory Suppression
16.1%
70%
Motor Impairment
12.9%
70%
Psychosis
9.7%
70%
Combinations
Cross-Check Lamotrigine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 3 reports 3 cautionary visit
Context: In June of 2012, I suffered a head injury at work. A concussion has left me in a somewhat damaged state, as it frequently does, and I have concentration, anger, and mania issues, as well as memory loss, word-recall impairment, motor function impairment, and general malaise.
A handful of years back I was diagnosed with epilepsy after having two fits in a day, one while at work (didn't know it was a seizure at first so I just thought I stood up too fast and continued on with my day) and the other a few hours later while driving.
Pill Identifiers
69
known pill identifiers on record — view imprints, colors, shapes, and images
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Lamotrigine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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