Lamotrigine
Aliases: Ltg, Lamictal, Subvenite, Lamictal xr, Lamictal odt
Categories
Summary
Self-reports cluster around four oral bands: a perceptible threshold cognitive lift at 12.5-25 mg, functional mood balance between 50-150 mg, pronounced but sedating effects at 200-300 mg, and heavy 400 mg+ experiments that many posters later regret. Clinical references corroborate a long half-life (25-33 h) and flag potent pharmacokinetic interactions—valproate can double lamotrigine levels, while carbamazepine or ethinylestradiol can halve them—explaining several adverse-event threads on harm-reduction boards. Titration must start at 25 mg every other day to avoid rash; typical maintenance 100-200 mg divided once or twice daily. Users experimenting above 300 mg risk severe dermatological reactions and ataxia. Reports also note lamotrigine dulls psychedelic visuals and blunts dissociative effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | - | - | 300mg+(rashrisk↑↑)+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 1-3 hrs | 4-8 hrs | 8-16 hrs | 24-48 hrs |
Tolerance
Effects
- Anxiolysis
- Ataxia
- Rash or Itching
- Motor impairment
- Fine hand tremor
- Weight gain
- Mild Sedation
- Sedation
- Polyuria
- Polydipsia
- Subtle Mood Lifting
- Cognitive Clarity
- Reduced anxiety
- Decreased suicidal ideation
- Dizziness
- Mild cognitive dulling
- Mood stabilization
- Emotional dampening
- Reduced emotional reactivity
- Reduced creativity
- Physical enhancement
- Light sensitivity
- Disinhibition
- Appetite suppression
- Spatial disorientation
- Derealization
- Dulled perception
- Metallic taste
- Visual distortions
- Visual disconnection