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    Disclaimer
    ☠ This is an extremely potent opioid active in microgram doses. Accidental overdose can be rapidly fatal. Naloxone should always be on hand.
    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Lofentanil Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: R-32792, R-34995, 3-methyl-4-carbomethoxyfentanyl

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Due to a sub-microgram active range, ordinary analytical balances cannot measure a non-lethal dose; volumetric dilution under inert atmosphere is essential. Naloxone may require large, repeated boluses because of lofentanil's long receptor residence time. This is one of the most potent opioids known, approximately 6000 times more potent than morphine, and has an extremely long duration of action compared to other fentanyl analogs.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Intravenous 0.1-0.3Β΅g 0.3-1Β΅g 1-2Β΅g 2Β΅g+
    In 0.2-0.6Β΅g 0.6-1.5Β΅g 1.5-3Β΅g 3Β΅g+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.0
    Strong+ 7/10

    Strong euphoria, itching/nausea, and pain relief with low sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria warmth mood lift
    Analgesia ×2
    8
    pain relief analgesia
    Sedation / Relaxation ×1
    3
    sedation
    ⚠ Itching / Nausea ×1
    10
    itching nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Lofentanil
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks β€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 2d Half tolerance 7d Baseline ~42d

    Based on general opioid patterns and limited analog data: tolerance can rise quickly with continuous exposure and decays over weeks. Estimates are approximate and carry low confidence.

    Cross-Tolerances

    μ‑opioid agonists (e.g., fentanyl, morphine)
    70%
    κ‑opioid agonists
    30%

    Effects TheDrug.Wiki

    Positive
    • Pain relief
    • Physical euphoria
    • Analgesia
    • Cough suppression
    Negative
    • Respiratory depression
    • Nausea
    • Itching
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Reduced anxiety
    • Euphoria
    • Mood lift
    Negative
    • Compulsive redosing
    • Constipation
    • Dizziness
    • Motor control loss
    Neutral
    • Physical autonomy
    Positive
    • Warmth
    • Color enhancement
    • Increased music appreciation
    • Brightened colour
    Negative
    • Light sensitivity
    • Appetite suppression
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Drifting

    Combinations TripSit

    Cross-Check Lofentanil with another substance

    Lofentanil's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    πŸ“˜ Experience Reports πŸ“– TheDrug.Wiki πŸ“– PsychonautWiki