Lofentanil
Aliases: R-32792, R-34995, 3-methyl-4-carbomethoxyfentanyl
Categories
Summary
Due to a sub-microgram active range, ordinary analytical balances cannot measure a non-lethal dose; volumetric dilution under inert atmosphere is essential. Naloxone may require large, repeated boluses because of lofentanil's long receptor residence time. This is one of the most potent opioids known, approximately 6000 times more potent than morphine, and has an extremely long duration of action compared to other fentanyl analogs.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | - | - | - | 2ug+(rapidlylethal)+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Intravenous | 1-2 min | 10-30 min | 4-6 hrs | 2-6 hrs |
| Intranasal | 5-10 min | 10-30 min | 4-6 hrs | 2-6 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Pain relief
- Physical euphoria
- Analgesia
- Cough suppression
Negative
- Respiratory depression
- Nausea
- Itching
- Sedation
- Itchiness
- Pupil constriction
Positive
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Euphoria
- Mood lift
Negative
- Compulsive redosing
- Constipation
- Dizziness
- Motor control loss
- Physical autonomy
Positive
- Warmth
- Color enhancement
- Increased music appreciation
- Brightened colour
Negative
- Light sensitivity
- Appetite suppression
- Disinhibition
- Dehydration
- Dulled perception
- Drifting