Lofentanil
Aliases: R-32792, R-34995, 3-methyl-4-carbomethoxyfentanyl
Summary
Due to a sub-microgram active range, ordinary analytical balances cannot measure a non-lethal dose; volumetric dilution under inert atmosphere is essential. Naloxone may require large, repeated boluses because of lofentanil's long receptor residence time. This is one of the most potent opioids known, approximately 6000 times more potent than morphine, and has an extremely long duration of action compared to other fentanyl analogs.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | - | - | - | 2ug+(rapidlylethal)+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Intravenous | 1-2 min | 10-30 min | 4-6 hrs |
| Intranasal | 5-10 min | 10-30 min | 4-6 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria, itching/nausea, and pain relief with low sedation
Tolerance
Tolerance Decay
Based on general opioid patterns and limited analog data: tolerance can rise quickly with continuous exposure and decays over weeks. Estimates are approximate and carry low confidence.
Cross-Tolerances
Effects
- Pain relief
- Physical euphoria
- Analgesia
- Cough suppression
- Respiratory depression
- Nausea
- Itching
- Sedation
- Itchiness
- Pupil constriction
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Euphoria
- Mood lift
- Compulsive redosing
- Constipation
- Dizziness
- Motor control loss
- Physical autonomy
- Warmth
- Color enhancement
- Increased music appreciation
- Brightened colour
- Light sensitivity
- Appetite suppression
- Disinhibition
- Dehydration
- Dulled perception
- Drifting