[This report originally appeared as typewritten page pasted into Book 3, pages 325 of the Shulgin Lab Books.] REPORT OF EXPERIENCE WITH MDOH On June 30, 1979, 10:30AM., ingested 100 m.g. of MDOH along with [Redacted], Sasha, Anne, [Redacted]. This time the drug seemed much slower coming on than in my initial trial.
MDOH
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- partial dose data
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- partial dose data
- duration data present
- 19 combo interactions documented
- classified Tentative
- classified Research-chemical
Summary
An entactogen, stimulant and psychedelic first synthesised by Alexander Shulgin, MDOH is an analogue of MDA. Described as highly psychedelic, it is likely a serotonin releasing agent. It has not seen widespread use, perhaps due to a number of reported negative side effects such as urinary retention and a heavy comedown.
Perspectives
“I felt hampered the first hour by some internal barrier, which prevented total enjoyment. However, this began to break through in a wonderful way just before the supplement was offered. Since I felt I was beginning to move through the barrier, I declined the supplement, particularly since I was anxious to compare the after-effects with my first experience. I had found the first time very remarkable, but felt unusually tired for several days following. I feel it is important to know whether this is a specific drug-induced effect, or the result of psychological phenomena. The experience continued in a rich, meaningful way. There was a marvelous inner glow, the warmth from all the other participants was wonderful to feel, nature was most beautiful. There were no dramatic breakthroughs, or rushes of insight or energy, but just a wonderful contemplative space where things gently unfolded as you put your attention on them.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-120mg | 120-150mg | - | 150mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 20-40 min | 4-6 hrs | 4-6 hrs |
Effect Profile
1 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
2.4
Light
2/10
Strong body load with mild visuals, low headspace
Visual Intensity
×3
5
color enhancement
tracers
pattern recognition enhancement
Headspace Depth
×3
1
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
9
nausea
vasoconstriction
teeth grinding
increased heart rate
sweating
Empathogen
4.6
Moderate+
5/10
Moderate stimulation, sensory enhancement, and euphoria with low empathy
Empathy / Social Openness
×3
2
increased sociability
Euphoria / Mood Elevation
×2
6
euphoria
cognitive euphoria
Stimulation
×1
7
stimulation
wakefulness
teeth grinding
increased heart rate
Sensory Enhancement
×1
7
tactile enhancement
color enhancement
increased libido
Stimulant
4.8
Moderate+
5/10
Strong anxiety/jitters with moderate stimulation and euphoria, mild focus
Stimulation / Energy
×3
6
stimulation
wakefulness
alertness enhancement
Euphoria / Mood Lift
×2
6
euphoria
cognitive euphoria
Focus / Productivity
×2
4
analysis enhancement
thought acceleration
Anxiety / Jitters
×1
10
anxiety
increased heart rate
teeth grinding
vasoconstriction
sweating
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Stimulation
- Increased energy/alertness
Negative
- Increased heart rate
- Pupil dilation
- Teeth grinding
- Nausea
- Vasoconstriction
- Increased perspiration
- Sweating
- Decreased appetite
Positive
- Alertness enhancement
- Euphoria
- Wakefulness
- Cognitive euphoria
- Analysis enhancement
- Increased sociability
Negative
- Anxiety
- Talkativeness
- Thought acceleration
- Time distortion
Positive
- Increased music appreciation
- Tactile enhancement
- Increased libido
- Tracers
- Color enhancement
- Pattern recognition enhancement
Negative
- Light sensitivity
- Dehydration
- Appetite suppression
- Increase sexuality
Combinations
Cross-Check MDOH with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 1 report 1 neutral visit
PiHKAL / TiHKAL
PiHKAL #114: MDOH
“I felt hampered the first hour by some internal barrier, which prevented total enjoyment. However, this began to break through in a wonderful way just before the supplement was offered. Since I felt I was beginning to move through the barrier, I declined the supplement, particularly since I was anxious to compare the after-effects with my first experience. I had found the first time very remarkable, but felt unusually tired for several days following. I feel it is important to know whether this is a specific drug-induced effect, or the result of psychological phenomena. The experience continued in a rich, meaningful way. There was a marvelous inner glow, the warmth from all the other participants was wonderful to feel, nature was most beautiful. There were no dramatic breakthroughs, or rushes of insight or energy, but just a wonderful contemplative space where things gently unfolded as you put your attention on them.”
MDOH's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for MDOH? Let us know. Reports are reviewed by moderators — this is not posted publicly.