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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    MDPA

    Aliases: Methylenedioxyphenylacetamide

    Psychedelic Empathogen Research-chemical Opioid

    Summary TripSit

    An obscure substituted methylenedioxyphenethylamine with practically no history of human use. Its pharmacological profile is largely unknown, but potentially exhibits similar properties to other MDxx compounds. May be a monoamine releaser, reuptake inhibitor or both.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 75-125mg 125-175mg 175-250mg 250+mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak Total
    Oral 15-45 min 2-4 hrs 2.2-4.8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 3.5
    Moderate 4/10

    Strong body load with moderate visuals, low headspace

    Visual Intensity ×3
    6
    color enhancement tracers pattern recognition enhancement visual distortions
    Headspace Depth ×3
    3
    introspection time distortion
    Auditory Effects ×1
    0
    ⚠ Body Load / Somatic Effects ×1
    9
    nausea vasoconstriction teeth grinding increased heart rate sweating
    Empathogen 4.6
    Moderate+ 5/10

    Moderate stimulation, sensory enhancement, and euphoria with low empathy

    Empathy / Social Openness ×3
    2
    increased sociability
    Euphoria / Mood Elevation ×2
    6
    euphoria cognitive euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    7
    tactile enhancement color enhancement increased libido
    Opioid 3.3
    Light+ 3/10

    Moderate euphoria with mild itching/nausea

    Euphoria / Warmth ×3
    6
    euphoria cognitive euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    0
    ⚠ Itching / Nausea ×1
    5
    nausea sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki MDPA
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects

    Positive
    • Stimulation
    Negative
    • Increased heart rate
    • Pupil dilation
    • Teeth grinding
    • Nausea
    • Vasoconstriction
    • Increased perspiration
    • Sweating
    Neutral
    • Dilated pupils
    • Decreased appetite
    Positive
    • Introspection
    • Euphoria
    • Wakefulness
    • Cognitive euphoria
    • Analysis enhancement
    • Increased sociability
    • Motivation enhancement
    Negative
    • Anxiety
    Neutral
    • Thought acceleration
    • Time distortion
    Positive
    • Color enhancement
    • Increased music appreciation
    • Tactile enhancement
    • Increased libido
    • Tracers
    • Pattern recognition enhancement
    Negative
    • Dehydration
    • Appetite suppression
    • Light sensitivity
    Neutral
    • Visual distortions

    Combinations TripSit

    MDPA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TripSit 📖 PsychonautWiki