Medazepam
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 17 combo interactions documented
- PubChem toxicity data
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 17 combo interactions documented
- PubChem toxicity data
Aliases: Talis, Resmit, Narsis, Nobrium, Rudotel, azepamid, raporan, mezapam
Summary
Medazepam is a long-acting benzodiazepine prodrug that metabolizes to diazepam and nordazepam, producing prolonged anxiolytic and sedative effects. Due to its very long half-life (36-200 hours) and active metabolites, the drug accumulates with repeated dosing, increasing risks of sedation and cognitive impairment. Withdrawal can be severe after prolonged use and requires medical supervision with gradual dose reduction.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-40mg | 40mg+ |
Benzo Equivalence Calculator
| Substance | Equivalent Dose | Potency |
|---|
⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Total |
|---|---|---|---|---|
| Oral | 30-60 min | 30-90 min | 1-2 hrs | 8-16 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiolysis, cognitive impairment, and euphoria with mild sedation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Medazepam there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Medazepam Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 5-10 · common 10-20 · strong 20-40 · heavy 40+ Oral duration: onset 0.5-1h · come-up 0.5-1.5h · peak 1-2h · total 8-16h · after-effects 1-172h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Hypnotic/sedative tolerance tends to develop within days–weeks; anxiolytic/anticonvulsant tolerance is slower and incomplete. Tolerance decays gradually over 2–6 weeks after cessation, but protracted symptoms may persist in a subset. Data largely extrapolated from benzodiazepine class literature and clinical experience (Ashton manual, StatPearls).
Cross-Tolerances
Effects
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
- Respiratory depression
- Motor impairment
- Sedation
- Sedative
- Dystaxia
- Hypnotic
- Anxiety suppression
- Cognitive euphoria
- Motor control loss
- Memory suppression
- Thought deceleration
- Emotion suppression
- Dizziness
- Amnesia
- Compulsive redosing
- Delusions of sobriety
- Increased libido
- Appetite enhancement
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Decreased Libido
- Double vision
- Dulled perception
- Perception of bodily heaviness
Combinations
Cross-Check Medazepam with another substanceHelpful Links
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