Medazepam
Aliases: Talis, Resmit, Narsis, Nobrium, Rudotel, azepamid, raporan, mezapam
Categories
Summary
Medazepam is a long-acting benzodiazepine prodrug that metabolizes to diazepam and nordazepam, producing prolonged anxiolytic and sedative effects. Due to its very long half-life (36-200 hours) and active metabolites, the drug accumulates with repeated dosing, increasing risks of sedation and cognitive impairment. Withdrawal can be severe after prolonged use and requires medical supervision with gradual dose reduction. Elderly patients and those with hepatic impairment should use reduced doses.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-40mg | 40mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 30-90 min | 1-2 hrs | 60-0 min | 480-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Anxiolytic
- Muscle Relaxant
Negative
- Respiratory depression
- Motor impairment
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Motor control loss
- Memory suppression
- Thought deceleration
- Emotion suppression
- Dizziness
- Amnesia
- Compulsive redosing
- Delusions of sobriety
Positive
- Increased libido
- Appetite enhancement
Negative
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Decreased Libido
- Acuity Suppression
- Double vision
- Dulled perception
- Perception of bodily heaviness