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    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Medazepam

    Aliases: Talis, Resmit, Narsis, Nobrium, Rudotel, azepamid, raporan, mezapam

    Depressant Benzodiazepine

    Summary TheDrug.Wiki TripSit

    Medazepam is a long-acting benzodiazepine prodrug that metabolizes to diazepam and nordazepam, producing prolonged anxiolytic and sedative effects. Due to its very long half-life (36-200 hours) and active metabolites, the drug accumulates with repeated dosing, increasing risks of sedation and cognitive impairment. Withdrawal can be severe after prolonged use and requires medical supervision with gradual dose reduction.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-20mg 20-40mg 40mg+
    Light Common Strong Heavy

    Benzo Equivalence Calculator

    mg
    10.0 mg Medazepam
    =
    — mg Diazepam

    ⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak After Effects Total
    Oral 30-60 min 30-90 min 1-2 hrs 1-172 hours 2-4.5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.1
    Strong+ 7/10

    Strong anxiolysis, cognitive impairment, and euphoria with mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    10
    motor control loss memory suppression amnesia delusions of sobriety double vision
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Medazepam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 28d Half tolerance 14d Baseline ~42d

    Hypnotic/sedative tolerance tends to develop within days–weeks; anxiolytic/anticonvulsant tolerance is slower and incomplete. Tolerance decays gradually over 2–6 weeks after cessation, but protracted symptoms may persist in a subset. Data largely extrapolated from benzodiazepine class literature and clinical experience (Ashton manual, StatPearls).

    Cross-Tolerances

    Other benzodiazepines
    90%
    Barbiturates
    30%

    Effects TheDrug.Wiki

    Positive
    • Muscle relaxation
    • Physical euphoria
    • Anxiolytic
    • Muscle Relaxant
    Negative
    • Respiratory depression
    • Motor impairment
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Motor control loss
    • Memory suppression
    • Thought deceleration
    • Emotion suppression
    • Dizziness
    • Amnesia
    • Compulsive redosing
    • Delusions of sobriety
    Positive
    • Increased libido
    • Appetite enhancement
    Negative
    • Disinhibition
    • Acuity suppression
    • Visual acuity suppression
    • Decreased Libido
    • Acuity Suppression
    • Double vision
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Medazepam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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