Summary
MEM is a rare psychedelic amphetamine first synthesized by Alexander Shulgin and described in PiHKAL as entry #122. It is structurally related to mescaline and other DOx compounds. Human data is extremely limited, making effects unpredictable.
Perspectives
“I experienced some physical discomfort, but doesn’t that tell us about the work to be done, rather than the property of the material? The breakthrough I had was the following day (and this seems to be the way MEM operates, i.e., first the energy and expansion, next day insight) was of the highest value and importance for me. I was given a methodology for dealing with my shadow parts. No small gift. And I did it all alone and the results were immediate. I am so grateful.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 15-25mg | 25-35mg | 35-45mg+ | 45mg++ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 3-6 hrs | 3-6 hrs | 7.5-15.5 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong visuals with moderate body load, mild headspace
Strong anxiety/jitters with low stimulation, euphoria, and focus
Tolerance
Tolerance Decay
Tolerance patterns extrapolated from LSD/2C-x data: marked acute tachyphylaxis with partial recovery over 3–7 days and near-baseline by ~1–2 weeks, though exact values for MEM are unstudied.
Cross-Tolerances
Effects
- Stimulation
- Mental/physical stimulation
- Vasoconstriction
- Pupil dilation
- Increased heart rate
- Restlessness
- Sweating/chills
- Muscle tension
- Insomnia
- Decreased appetite
- Euphoria
- Analysis enhancement
- Conceptual thinking
- Empathy enhancement
- Empathy
- Insight
- Anxiety
- Confusion
- Time distortion
- Change in perception
- Ego softening
- Visual enhancement
- Color enhancement
- Pattern recognition enhancement
- Tactile enhancement
- Brightened colour
- Enhanced tactile sensation
- Increased music appreciation
- Light sensitivity
- Drifting
- Closed/Open eye visuals
Combinations
PiHKAL / TiHKAL
“I experienced some physical discomfort, but doesn’t that tell us about the work to be done, rather than the property of the material? The breakthrough I had was the following day (and this seems to be the way MEM operates, i.e., first the energy and expansion, next day insight) was of the highest value and importance for me. I was given a methodology for dealing with my shadow parts. No small gift. And I did it all alone and the results were immediate. I am so grateful.”