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    Methcathinone molecular structure

    Methcathinone Stats & Data

    Mc Cat Kat Jeff M-kat
    NPS DataHub
    MW163.22
    FormulaC10H13NO
    CAS5650-44-2
    IUPAC2-methylamino-1-phenylpropan-1-one
    SMILESCNC(C)C(=O)c1ccccc1
    InChIKeyLPLLVINFLBSFRP-UHFFFAOYSA-N
    Phenethylamines Cathinones
    Chemical Class Substituted cathinone
    Psychoactive Class Stimulant

    Pharmacology

    DrugBank

    Description

    Methcathinone is under investigation in clinical trial NCT02617862 (PCI Imaging System in Pediatric Ophthalmology).

    Receptor Profile

    Receptor Actions

    Inhibitors
    Dopamine reuptake inhibitor
    Norepinephrine reuptake inhibitor

    History & Culture

    Methcathinone was first synthesized in the United States in 1928. The compound was subsequently patented by the pharmaceutical company Parke-Davis in 1957. During the 1930s and 1940s, the Soviet Union employed the substance therapeutically as an antidepressant, where it was known as ephedrone (Эфедрон in Russian). Over time, methcathinone became established as a recreational substance in the Soviet Union and later in Russia, where it developed a long history of non-medical use. International efforts to control methcathinone began in the mid-1990s when the United States government recommended to the United Nations Secretary-General that the substance be added to Schedule I of the Convention on Psychotropic Substances around 1994. Following this recommendation, China added methcathinone to its list of prohibited substances in 1995 and ceased any remaining pharmaceutical applications. The substance remains prevalent in central and eastern European regions, where it is sometimes misrepresented as the more widely recognized cathinone derivative mephedrone. It is also frequently synthesized clandestinely from over-the-counter medications containing ephedrine or pseudoephedrine.

    Effect Profile

    Curated + 13 Reports
    Empathogen 5.6

    Moderate stimulation and euphoria with mild empathy and sensory enhancement

    Empathy / Social Openness×3
    5
    Euphoria / Mood Elevation×2
    6
    Stimulation×1
    7
    Sensory Enhancement×1
    5
    Stimulant 5.9

    Strong focus with strong anxiety/jitters, moderate euphoria, mild stimulation

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    7
    Focus / Productivity×2
    9
    Anxiety / Jitters×1
    10
    Based on reports from:

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    ~1.5–2 hours
    Addiction Potential
    High — compulsive redosing and binge patterns are commonly reported for short-acting stimulants of this class.

    Tolerance Decay

    Full tolerance 2d Half tolerance 4d Baseline ~10d

    Rapid tolerance is commonly reported with repeated use over days; rough decay to baseline over ~1–2 weeks is inferred from community reports and stimulant analogues. Data quality is limited and interindividual variability is high.

    Cross-Tolerances

    Amphetamines
    Other cathinones

    Experience Report Analysis

    Erowid
    17 Reports
    13 Single-substance
    1993–2012 Date Range
    1 With Age Data
    10 Effects Detected

    Demographics

    Gender Distribution

    Too few reports for a chart: gender is known from 17 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Not Specified 2 of 17
    • Male 14 of 17
    • Female 1 of 17

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 13 experience reports (13 single-substance Erowid)

    13 Reports
    10 Effects Detected
    4 Positive
    5 Adverse
    1 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

    Too few reports for bars: these effects come from 13 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    Positive Effects 4

    Stimulation 9 of 13 70%
    Euphoria 7 of 13 70%
    Focus Enhancement 3 of 13 70%
    Empathy 3 of 13 70%

    Adverse Effects 5

    Anxiety 6 of 13 70%
    Confusion 4 of 13 70%
    ⚠ Psychosis 3 of 13 70%
    Nausea 3 of 13 70%
    Muscle Tension 3 of 13 70%
    Show 1 neutral or unclassified mention
    Sedation 5 of 13

    Also reported in combinations. In the 4 Methcathinone reports where another drug was taken too, 0 mention hospital, emergency services or an overdose, 1 a seizure and 0 psychosis (too few reports for percentages). In the 13 single-substance reports: 0, 2 and 3. These are not in the figures above: they cannot be put down to Methcathinone alone, and a mention is not always something that happened to the writer.

    Real-World Dose Distribution

    Erowid

    From 7 of 12 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

    Oral (n=7)

    Median: 100.0mg 25th: 82.5mg 75th: 137.5mg 90th: 217.0mg

    Form / Preparation

    Most common forms and preparations, as a share of the 9 reports that give one

    Too few reports for bars: these forms come from 9 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

    • Powder / Crystals 7 of 9

    Redose Patterns

    Redosing behavior across 10 reports

    2 of 10 Redosed
    1.3 Avg Doses

    Too few reports for a chart: redosing is known from 10 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Single dose 8 of 10
    • Redosed 2 of 10

    Legal Status

    UN Convention on Psychotropic Substances 1971 (Schedule I)
    Country Status Notes
    Australia Schedule 9 Classified as a Schedule 9 prohibited substance under the Poisons Standard. Schedule 9 substances are considered to have no therapeutic use and high potential for abuse, making possession, production, and distribution illegal without specific authorization.

    Harm Reduction

    drugs.wiki

    Injecting or otherwise using methcathinone made with potassium permanganate (a common home synthesis) has been repeatedly linked to irreversible manganese-induced parkinsonism; avoid any preparation of uncertain origin and never inject — Mn-related damage does not improve after cessation. Early signs include gait disturbance, hypophonia, and falls; MRI classically shows T1 hyperintensity of the globus pallidus. Redosing pressure is high due to the short duration; spacing doses and setting a firm session cap reduces binge risk and sleep deprivation. Like other stimulants, methcathinone can acutely raise heart rate and blood pressure; those with cardiovascular disease, hypertension, or arrhythmia risk should avoid use and everyone should avoid strenuous exertion while under the influence. Combining with MAOIs is hazardous (hypertensive crises, hyperthermia) and should be strictly avoided; combining with tramadol or bupropion increases seizure risk. Mixing with alcohol increases dehydration and cardiostress while masking intoxication; with benzodiazepines, sedation can mask stimulant overuse and encourage redosing — treat as a caution-only combination reserved for managing severe agitation. Insufflation is irritating/caustic; use tiny test lines, rotate nostrils, rinse with saline after, and allow mucosa to recover between sessions. Use a precise milligram scale, lab‑verified material when possible, and consider reagent testing/drug checking to rule out substitutions or manganese contamination. Expect a comedown (anxiety, dysphoria, insomnia); nutrition, hydration, and planning sleep ahead of time reduce harm. Frequent use builds tolerance rapidly and can drive dose escalation; spacing sessions (≥1–2 weeks) reduces risk of dependency and persistent mood changes.

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