Summary
Methcathinone is a Schedule I controlled substance internationally and in the US. Illicit synthesis using potassium permanganate oxidation of ephedrine/pseudoephedrine has been associated with manganese-induced neurotoxicity resembling Parkinson's disease symptoms. Causes severe dehydration and increased perspiration requiring constant hydration to prevent rhabdomyolysis. Known for inducing mania more than methamphetamine but with less associated psychosis. Structurally related to methamphetamine with addition of a ketone group.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-100mg | 100-200mg | 200-300mg | 300mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 10-30 min | 30-60 min | 1-2 hrs | 1-2 hrs | 2-6 hrs |
| Insufflated | 5-10 min | 15-30 min | 1-2 hrs | 1-2 hrs | 2-6 hrs |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Increased heart rate
- Increased blood pressure
- Increased perspiration
- Teeth grinding
- Vasoconstriction
- Temperature regulation suppression
- Muscle contractions
- Difficulty urinating
Positive
- Cognitive euphoria
- Motivation enhancement
- Analysis enhancement
- Focus enhancement
- Increased sociability
- Empathy enhancement
- Wakefulness
Negative
- Anxiety
- Compulsive redosing
- Paranoia
- Psychosis
- Thought acceleration
- Thought organization
- Time distortion
Positive
- Increased music appreciation
- Increased libido
- Tactile enhancement
Negative
- Appetite suppression
- Dehydration
- Disinhibition
- Vibrating vision
- Spontaneous physical sensations
- Increase sexuality
- Visual and audiotory hallucinations itchiness