Summary
Methiopropamine has very little history of human use and limited scientific data exists about its pharmacology and toxicity. The substance is controlled in many jurisdictions including the US (Schedule I federally), UK (Class B), Germany, France, Switzerland, China, Austria, Brazil, and Florida. Use accurate scales for dosing and be aware that the substance has been associated with cardiovascular toxicity, gastrointestinal symptoms, and psychotic symptoms. Small increases in dosage may engender unexpectedly strong effects and heighten the risk of unintended overdose. Individuals with cardiovascular conditions or predisposition to psychosis should avoid use.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-30mg | 30-50mg | 50-60mg | 60mg+ |
| Insufflated | 5-20mg | 20-40mg | 40-60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-60 min | 30-60 min | 2-4 hrs | 2-3 hrs | 1-2 hrs | 360-0 min |
| Insufflated | 5-10 min | 10-20 min | 30-60 min | 0.5-2 hrs | 6-8 hrs | 120-0 min |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Effects
Positive
- Stimulation
- Spontaneous Tactile Sensations
- Physical euphoria
Negative
- Increased Perspiration
- Teeth Grinding
- Increased Heart Rate
- Temperature Regulation Suppression
- Increased heart rate
- Nausea
- Sedation
Positive
- Focus Enhancement
- Motivation Enhancement
- Cognitive Euphoria
- Wakefulness
- Analysis Enhancement
Negative
- Compulsive Redosing
- Anxiety
- Cognitive fatigue
- Depression
- Irritability
- Thought deceleration
- Thought Acceleration
- Thought Organization
Positive
- Increased Libido
- Increased Music Appreciation
- Increased music appreciation
- Increased libido
Negative
- Appetite Suppression
- Light sensitivity
- Disinhibition
- Appetite suppression
- Dehydration
- Dulled perception