Summary
Methocarbamol is a centrally-acting skeletal muscle relaxant with sedative properties used for acute musculoskeletal pain. It should be avoided in geriatric patients due to increased fall risk and is contraindicated in myasthenia gravis. The injectable form is contraindicated in renal impairment. Seizures have been reported, particularly with IV administration or in patients with epilepsy history. Not recommended during pregnancy or breastfeeding.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 1-2 hrs | 2-4 hrs | 6-8 hrs |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Positive
- Muscle relaxation
- Physical euphoria
- Pain relief
- Anxiolytic
- Muscle Relaxant
Negative
- Motor impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Dizziness
- Drowsiness
- Cognitive impairment
- Motor control loss
- Dysphoria
- Thought deceleration
- Amnesia
- Analysis suppression
Positive
- Increased libido
- Appetite enhancement
Negative
- Disinhibition
- Acuity suppression
- Decreased Libido
- Acuity Suppression
- Double vision
- Visual acuity suppression
- Dulled perception
- Perception of bodily heaviness