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    Disclaimer
    โ˜  This is an extremely potent opioid active in microgram doses. Accidental overdose can be rapidly fatal. Naloxone should always be on hand.
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Methoxyacetyl-Fentanyl Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical

    Aliases: Maf, Desfluoroocfentanil

    Summary TripSit

    A quite potent fentanyl analogue.

    Dose Information TripSit

    Dose basis. TripSit is the only source for these figures and states three tiers ending in an open "Strong: 1.5 mg and above" โ€” there is no Heavy band and no established ceiling. The numbers are compiled from user reports rather than measured, on a fentanyl analogue where the difference between tiers is a fraction of a milligram.

    ROA Light Common Strong Heavy
    Oral 0.25-0.5mg 0.5-1.5mg 1.5mg+ -
    Light Common Strong Heavy

    Effect Profile

    class estimate

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • No reports exist for this substance. Its effect list is the one shared by 1 other substance of the same class, so the scores below describe the class, not this compound.
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 5.4
    Moderate+ 5/10

    Strong euphoria with mild sedation and itching/nausea

    Euphoria / Warmth ×3
    9
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    5
    sedation muscle relaxation
    Itching / Nausea ×1
    4
    nausea

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Methoxyacetyl-Fentanyl there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    Methoxyacetyl-Fentanyl
    Unit
    mg
    Description
    Methoxyacetyl-Fentanyl
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): light 0.25-0.5 ยท common 0.5-1.5 ยท strong 1.5+
    
    Oral duration: after-effects 1-4h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7โ€“14 days for partial reset; full reset may take weeks โ€” tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects

    Positive
    • Stimulation
    • Physical euphoria
    • Muscle relaxation
    Negative
    • Motor impairment
    • Increased heart rate
    • Nausea
    • Vasoconstriction
    • Respiratory depression
    • Teeth grinding
    Neutral
    • Sedation
    Positive
    • Reduced anxiety
    • Cognitive euphoria
    • Euphoria
    • Anxiety suppression
    • Wakefulness
    Negative
    • Anxiety
    • Compulsive redosing
    • Dizziness
    • Thought deceleration
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Increased libido
    • Tactile enhancement
    • Color enhancement
    Negative
    • Disinhibition
    • Appetite suppression
    • Dehydration
    • Light sensitivity
    • Double vision
    Neutral
    • Dulled perception

    Combinations TripSit

    Cross-Check Methoxyacetyl-Fentanyl with another substance

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