Methylenedioxyphenmetrazine
Aliases: Mdpm, 3-mdpm, 3,4-mdpm
Summary
MDPM is an extremely novel substance with virtually no human pharmacological data. It acts as a strong CYP2D6 inhibitor and moderate CYP3A4/CYP1A2 inhibitor, creating significant drug-drug interaction risks when combined with medications or substances metabolized by these enzymes. Often appears as a synthetic impurity in MDMA manufacture.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral | 15-40 min | 1-3 hrs | 2-4 hrs |
| Insufflated | 5-10 min | 1-3 hrs | 2-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
5.4
Moderate+
5/10
Strong anxiety/jitters and euphoria with mild stimulation and focus
Stimulation / Energy
×3
5
stimulation
increased energy
Euphoria / Mood Lift
×2
9
euphoria
cognitive euphoria
increased motivation
motivation enhancement
Focus / Productivity
×2
5
focus enhancement
motivation enhancement
Anxiety / Jitters
×1
10
anxiety
increased heart rate
teeth grinding
tachycardia
vasoconstriction
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
3d
Half tolerance
14d
Baseline
~28d
Model is heuristic for HR spacing guidance, not a pharmacometric estimate. Expect rapid tolerance with consecutive-day use and partial cross-tolerance with other stimulants. Data quality: anecdotal/theoretical.
Cross-Tolerances
Effects
Positive
- Stimulation
- Increased energy
- Increased energy/alertness
Negative
- Increased heart rate
- Teeth grinding
- Pupil dilation
- Insomnia
- Vasoconstriction
- Tachycardia
- Increased perspiration
Positive
- Increased motivation
- Focus enhancement
- Euphoria
- Empathy
- Motivation enhancement
- Increased sociability
- Cognitive euphoria
Negative
- Anxiety
- Compulsive redosing
- Time distortion
Positive
- Increased libido
- Increased music appreciation
Negative
- Appetite suppression
- Light sensitivity
- Tinnitus
- Dehydration
- Disinhibition
- Decreased libido
- Increase sexuality
- Visual and audiotory hallucinations itchiness
Combinations
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