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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Methylenedioxyphenmetrazine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Mdpm, 3-mdpm, 3,4-mdpm

    Stimulant Research-chemical

    Summary dose.wiki

    MDPM is an extremely novel substance with virtually no human pharmacological data. It acts as a strong CYP2D6 inhibitor and moderate CYP3A4/CYP1A2 inhibitor, creating significant drug-drug interaction risks when combined with medications or substances metabolized by these enzymes. Often appears as a synthetic impurity in MDMA manufacture.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Ranges are based on collated user reports from Reddit and Bluelight; large inter-batch potency variability likely. Always weigh with a 0.001 g scale, start at the low end, and confirm the salt form (HCl vs freebase) before interpreting milligram values. Do not redose until at least 90–120 minutes have passed due to delayed onset sometimes reported. Evidence quality: anecdotal user reports. User reports describe a faster onset but increased local irritation; prefer oral if possible. Use fine powdering and post-rinse with isotonic saline to limit nasal damage. Evidence quality: anecdotal. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-180mg 180-250mg 250mg+
    Insufflated 25-60mg 60-100mg 100-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 15-40 min 1-3 hrs 2-4 hrs 2-6 hrs 3.25-7.67 hrs
    Insufflated 5-10 min 1-3 hrs 2-4 hrs 2-6 hrs 3.08-7.17 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.4
    Moderate+ 5/10

    Strong anxiety/jitters and euphoria with mild stimulation and focus

    Stimulation / Energy ×3
    5
    stimulation increased energy
    Euphoria / Mood Lift ×2
    9
    euphoria cognitive euphoria increased motivation motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding tachycardia vasoconstriction
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Methylenedioxyphenmetrazine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Methylenedioxyphenmetrazine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Methylenedioxyphenmetrazine
    Unit
    mg
    Description 
    Methylenedioxyphenmetrazine
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 25-50 · light 50-100 · common 100-180 · strong 180-250 · heavy 250+
Insufflated dose (mg): threshold 10-25 · light 25-60 · common 60-100 · strong 100-150 · heavy 150+

Oral duration: onset 15-40m · peak 1-3h · offset 2-4h · total 3.25-7.67h · after-effects 2-6h
Insufflated duration: onset 5-10m · peak 1-3h · offset 2-4h · total 3.08-7.17h · after-effects 2-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 140 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Model is heuristic for HR spacing guidance, not a pharmacometric estimate. Expect rapid tolerance with consecutive-day use and partial cross-tolerance with other stimulants. Data quality: anecdotal/theoretical.

    Cross-Tolerances

    Amphetamine-class stimulants
    50%
    Phenmetrazine analogues (e.g., 3-FPM)
    60%

    Effects dose.wiki

    Positive
    • Stimulation
    • Increased energy
    • Increased energy/alertness
    Negative
    • Increased heart rate
    • Teeth grinding
    • Pupil dilation
    • Insomnia
    • Vasoconstriction
    • Tachycardia
    • Increased perspiration
    Positive
    • Increased motivation
    • Focus enhancement
    • Euphoria
    • Empathy
    • Motivation enhancement
    • Increased sociability
    • Cognitive euphoria
    Negative
    • Anxiety
    • Compulsive redosing
    Neutral
    • Time distortion
    Positive
    • Increased libido
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Light sensitivity
    • Tinnitus
    • Dehydration
    • Disinhibition
    • Decreased libido
    Neutral
    • Increase sexuality
    • Visual and audiotory hallucinations itchiness

    Combinations

    Cross-Check Methylenedioxyphenmetrazine with another substance

    Methylenedioxyphenmetrazine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki