Summary
MDPM is an extremely novel substance with virtually no human pharmacological data. It acts as a strong CYP2D6 inhibitor and moderate CYP3A4/CYP1A2 inhibitor, creating significant drug-drug interaction risks when combined with medications or substances metabolized by these enzymes. Often appears as a synthetic impurity in MDMA manufacture. Confirm identity with spectroscopy before use. Use professional reagent testing, employ allergy tests, and practice incremental dosing.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 15-40 min | 1-3 hrs | 2-4 hrs | 2-6 hrs |
| Insufflated | 5-10 min | 1-3 hrs | 2-4 hrs | 2-6 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Effects
Positive
- Stimulation
- Increased energy
- Increased energy/alertness
Negative
- Increased heart rate
- Teeth grinding
- Pupil dilation
- Insomnia
- Vasoconstriction
- Tachycardia
- Increased perspiration
Positive
- Increased motivation
- Focus enhancement
- Euphoria
- Empathy
- Motivation enhancement
- Increased sociability
- Cognitive euphoria
Negative
- Anxiety
- Compulsive redosing
- Time distortion
Positive
- Increased libido
- Increased music appreciation
Negative
- Appetite suppression
- Light sensitivity
- Tinnitus
- Dehydration
- Disinhibition
- Decreased libido
- Increase sexuality
- Visual and audiotory hallucinations itchiness