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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Methylenedioxyphenmetrazine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Mdpm, 3-mdpm, 3,4-mdpm

    Stimulant Research-chemical

    Summary TheDrug.Wiki

    MDPM is an extremely novel substance with virtually no human pharmacological data. It acts as a strong CYP2D6 inhibitor and moderate CYP3A4/CYP1A2 inhibitor, creating significant drug-drug interaction risks when combined with medications or substances metabolized by these enzymes. Often appears as a synthetic impurity in MDMA manufacture.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-180mg 180-250mg 250mg+
    Insufflated 25-60mg 60-100mg 100-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-60 min 1-3 hrs 1-3 hrs 2-8 hrs 4-7 hrs
    Insufflated 30-60 min 1-3 hrs 1-3 hrs 2-8 hrs 4-7 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.4
    Moderate+ 5/10

    Strong anxiety/jitters and euphoria with mild stimulation and focus

    Stimulation / Energy ×3
    5
    stimulation increased energy
    Euphoria / Mood Lift ×2
    9
    euphoria cognitive euphoria increased motivation motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding tachycardia vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Methylenedioxyphenmetrazine
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~28d

    Model is heuristic for HR spacing guidance, not a pharmacometric estimate. Expect rapid tolerance with consecutive-day use and partial cross-tolerance with other stimulants. Data quality: anecdotal/theoretical.

    Cross-Tolerances

    Amphetamine-class stimulants
    50%
    Phenmetrazine analogues (e.g., 3-FPM)
    60%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Increased energy
    • Increased energy/alertness
    Negative
    • Increased heart rate
    • Teeth grinding
    • Pupil dilation
    • Insomnia
    • Vasoconstriction
    • Tachycardia
    • Increased perspiration
    Positive
    • Increased motivation
    • Focus enhancement
    • Euphoria
    • Empathy
    • Motivation enhancement
    • Increased sociability
    • Cognitive euphoria
    Negative
    • Anxiety
    • Compulsive redosing
    Neutral
    • Time distortion
    Positive
    • Increased libido
    • Increased music appreciation
    Negative
    • Appetite suppression
    • Light sensitivity
    • Tinnitus
    • Dehydration
    • Disinhibition
    • Decreased libido
    Neutral
    • Increase sexuality
    • Visual and audiotory hallucinations itchiness

    Combinations TripSit

    Cross-Check Methylenedioxyphenmetrazine with another substance

    Methylenedioxyphenmetrazine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki