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    Disclaimer
    ☠ Nitazene-class opioids are extremely potent, often exceeding fentanyl in strength. Even trace amounts can be fatal. Naloxone should always be on hand.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Metonitazene

    Aliases: Nitazene, Metonitazine

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Metonitazene is a high-potency synthetic benzimidazole opioid with potency similar to fentanyl (approximately 100 times morphine by central routes, 10 times orally). It has been found unexpectedly in counterfeit oxycodone pills, heroin, and other substances. Overdoses may require higher-than-normal doses of naloxone and multiple administrations to reverse.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset
    Oral 5-15 min 30-90 min 2-4 hrs
    Insufflated 1-5 min 30-90 min 2-4 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.6
    Intense 8/10

    Strong euphoria, itching/nausea, and pain relief with moderate sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria warmth
    Analgesia ×2
    8
    analgesia pain relief
    Sedation / Relaxation ×1
    7
    sedation drowsiness muscle relaxation
    ⚠ Itching / Nausea ×1
    10
    itching nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Metonitazene
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Cross-Tolerances

    Other opioids (e.g., fentanyl, morphine, heroin)
    70%

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    • Physical euphoria
    • Pain relief
    • Muscle relaxation
    Negative
    • Respiratory depression
    • Itching
    • Nausea
    Neutral
    • Sedation
    • Pinpoint pupils
    • Itchiness
    Positive
    • Reduced anxiety
    • Cognitive euphoria
    • Anxiety suppression
    • Wakefulness
    • Motivation enhancement
    • Euphoria
    Negative
    • Constipation
    • Drowsiness
    • Compulsive redosing
    • Motivation suppression
    Positive
    • Warmth
    • Increased music appreciation
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Warm flush
    • Internal hallucination

    Combinations TripSit

    Metonitazene's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki