Experiences with narcotics had been so far limited to relatively "manageable" products namely medical morphine and what is considered a "soft" RC, bucinnazine-237. I felt there were still some things left to experience in order to call it quits with narcotics.
Metonitazene
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Nitazene, Metonitazine
Summary
Metonitazene is a high-potency synthetic benzimidazole opioid with potency similar to fentanyl (approximately 100 times morphine by central routes, 10 times orally). It has been found unexpectedly in counterfeit oxycodone pills, heroin, and other substances. Overdoses may require higher-than-normal doses of naloxone and multiple administrations to reverse.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.1-0.2mg | 0.2-0.5mg | 0.5-1mg | 1mg+ |
| Insufflated | 0.05-0.1mg | 0.1-0.3mg | 0.3-0.6mg | 0.6mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 5-15 min | 30-90 min | 2-4 hrs | 4-8 hrs |
| Insufflated | 1-5 min | 30-90 min | 2-4 hrs | 4-8 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
7.6
Intense
8/10
Strong euphoria, itching/nausea, and pain relief with moderate sedation
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
warmth
Analgesia
×2
8
analgesia
pain relief
Sedation / Relaxation
×1
7
sedation
drowsiness
muscle relaxation
Itching / Nausea
×1
10
itching
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Half tolerance
7d
Baseline
~35d
Rapid tolerance is typical of high‑potency opioid agonists. Cross‑tolerance with other opioids is expected but incomplete and may not prevent overdose if switching substances. Data quality is limited due to variability in street samples and co‑use with other depressants.
Cross-Tolerances
Effects
Positive
- Analgesia
- Physical euphoria
- Pain relief
- Muscle relaxation
Negative
- Respiratory depression
- Itching
- Nausea
- Sedation
- Pinpoint pupils
- Itchiness
Positive
- Reduced anxiety
- Cognitive euphoria
- Anxiety suppression
- Wakefulness
- Motivation enhancement
- Euphoria
Negative
- Constipation
- Drowsiness
- Compulsive redosing
- Motivation suppression
Positive
- Warmth
- Increased music appreciation
- Increased libido
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Dulled perception
- Warm flush
- Internal hallucination
Combinations
Cross-Check Metonitazene with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 2 reports 1 neutral 1 cautionary visit
So I found this product on the interwebz, from a website that contributes to scientific research. They make a blend of base product with glycerine so that it could be used in vaping machines. Opium 2.0 in a sense. Looks badass but it's really just a narcotic which is "prepared" .
Metonitazene's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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