Mirtazapine - Substance Search

Summary TheDrug.Wiki Erowid PsychonautWiki

Mirtazapine (trade name Remeron and Mirta TAD, among others) is an antidepressant substance of the piperazinoazepine class. At high doses, it has been reported to act as an atypical psychedelic and sedative. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).

Dose Information TheDrug.Wiki PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral BA 50%	70-130mg	130-190mg	190-250mg	250mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

ROA	Onset	Peak	Offset	After Effects
Oral	15-60 min	1.5-3 hrs	2-6 hrs	12-24 hrs

Effect Profile

66 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 66 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 4.2

Moderate 4/10

Strong auditory effects with mild visuals and body load, low headspace

Visual Intensity ×3

5

autonomous entities

Headspace Depth ×3

2

time distortion

Auditory Effects ×1

8

auditory distortion

⚠ Body Load / Somatic Effects ×1

5

nausea

Based on reports from:

Effect Index Sleepy & Hungry Dreams Erowid Experience Reports PsychonautWiki Mirtazapine

Tolerance

Build-up develops rapidly after a single use (serotonergic psychedelic)

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 0h Half tolerance 7d Baseline ~30d

Formal human data on tolerance are limited. Clinically, sedation often diminishes over 1–4 weeks of regular nightly dosing (partial tolerance), while antidepressant benefits generally require sustained dosing and do not show euphoric tolerance patterns. No reliable evidence for cross‑tolerance with classic serotonergic psychedelics; many reports suggest mirtazapine blunts them. Data quality is mainly clinical observation and user reports.