Mirtazapine
Aliases: Axit, Avanza, Zispin, Mirtaz, Norset
Categories
Summary
At therapeutic doses (7.5-45mg), mirtazapine functions as a sedating antidepressant with appetite-stimulating effects. At higher doses (typically 100mg+), it produces atypical psychedelic and deliriant effects with extreme sedation but lacks introspective or recreational value. Paradoxically, lower doses (7.5mg) are more sedating than higher doses (30-45mg) due to offsetting noradrenergic effects. Not recommended for recreational use due to overwhelming sedation and lack of euphoria. Common side effects include weight gain, vivid dreams, dry mouth, and restless legs.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA 50% | 70-130mg | 130-190mg | 190-250mg | 250mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral | 15-60 min | 1.5-3 hrs | 2-6 hrs | 12-24 hrs |
Tolerance
Build-up
develops rapidly after a single use (serotonergic psychedelic)
Reset
7–14 days for baseline
Effects
Positive
- Stimulation
- Anxiolysis
- Increased energy
Negative
- Dry mouth
- Motor impairment
- Insomnia
- Nausea
- Headache
- Sedation
- Restless legs
Positive
- Dream potentiation
- Anxiety suppression
- Cognitive euphoria
Negative
- Motor control loss
- Emotion suppression
- Thought deceleration
- Amnesia
- Constipation
- Dizziness
- Time distortion
Positive
- Appetite enhancement
- Increased music appreciation
Negative
- Visual acuity suppression
- Light sensitivity
- Visual drifting
- Internal hallucination
- External hallucination
- Autonomous entities
- Tactile hallucination
- Auditory distortion