Morphine-N-oxide Stats & Data

Depressant Opioid

NPS DataHub

MW301.34

FormulaC17H19NO4

CAS639-46-3

IUPAC(4~{R},4~{a}~{R},7~{S},7~{a}~{R},12~{b}~{S})-3-methyl-3-oxido-2,4,4~{a},7,7~{a},13-hexahydro-1~{H}-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7,9-diol

SMILESOC1C=CC2C3Cc4ccc(O)c5OC1C2(CCN3(C)=O)c45

InChIKeyAMAPEXTUMXQULJ-APQDOHRLSA-N

Chemical Class Morphinan

Psychoactive Class Depressant

Effect Profile

Curated

Opioid 5.1

Strong euphoria with moderate itching/nausea, mild sedation

Euphoria / Warmth×3

Analgesia×2

Sedation / Relaxation×1

Itching / Nausea×1

Tolerance & Pharmacokinetics

drugs.wiki

No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

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