Before we jump into the details of MT-45, a little about myself. I have been around the block a bit myself with opioids before. In my flirtations with Lady Poppy, I have tasted several natural and synthetic opioids: heroin, kratom, opium, poppy tea (oddly enough, my favorite opiate of the bunch -- nothing can quite bea...
MT-45
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- classified Research-chemical
Aliases: Ic-6, mt45
Summary
A synthetic opioid drug that was rumoured to be roughly 80% the potency of Morphine orally. Was created by Dainippon Pharmaceutical in the 1970's. It has been used as a lead compound for the design of related substances.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 30-45mg | 45-60mg | 60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 30-45 min | 4-6 hrs | 4-6 hrs |
Effect Profile
4 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.3
Strong
6/10
Strong euphoria with moderate itching/nausea, mild pain relief, low sedation
Euphoria / Warmth
×3
10
physical euphoria
euphoria
cognitive euphoria
mood lift
Analgesia
×2
4
analgesia
Sedation / Relaxation
×1
3
sedation
Itching / Nausea
×1
7
nausea
constipation
dry mouth
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Analgesia
- Stimulation
- Physical euphoria
Negative
- Dry Mouth
- Increased heart rate
- Nausea
- Itchiness
- Relaxant
- Pupil constriction
- Sedation
Positive
- Euphoria
- Mood lift
- Reduced anxiety
- Cognitive euphoria
- Anxiety suppression
Negative
- Constipation
- Anxiety
- Compulsive redosing
- Dizziness
- Time distortion
Positive
- Increased music appreciation
- Increased libido
- Tactile enhancement
- Color enhancement
Negative
- Disinhibition
- Appetite suppression
- Dehydration
- Light sensitivity
- Double vision
- Dulled perception
Combinations
Cross-Check MT-45 with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 3 reports 3 neutral visit
I acquired a sample of this substance, not having much experience with opiates. This is supposedly an opiate analog that is 80% as potent as Morphine. I'd have to say from my initial study, that the statement is correct.
I acquired 1 gram. I had no real ideas about it besides what receptor it bound to (mu negative). A classic opioid it seemed. I have had experiences with vicodin/ oxyยs before (as in chew up a bit too many for my own good). The first time I tried it I did it as a suppository.
MT-45's nerd page
Pharmacology, chemical data, effect profiles, and more
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