Myristicin Stats & Data
BNWJOHGLIBDBOB-UHFFFAOYSA-NPharmacology
DrugBankMechanism of Action
To evaluate the hepatoprotective activity of spices, 21 different spices were fed to rats with liver damage caused by lipopolysaccharide (LPS) plus d-galactosamine (D-GalN). As assessed by plasma aminotranferase activities, nutmeg showed the most potent hepatoprotective activity. Bioassay-guided isolation of the active compound from nutmeg was carried out in mice by a single oral administration of the respective fractions. Myristicin, one of the major essential oils of nutmeg, was found to posse
Metabolism
In mice, the major metabolic pathway for ... myristicin includes cleavage of the methylenedioxyphenol residue and exhalation of the methylene carbon atom as carbon dioxide.
Toxicity
PubChemMyristicin exerts possible neurotoxic effects on dopaminergic neurons and is a weak inhibitor of monoamine oxidase. (L1271)
LD50
LD50: 3000 mg/kg (Oral, Mouse) (L1272)LD50: 340 mg/kg (Intraperitoneal, Mouse) (L1272)LD50: 5610 mg/kg (Dermal, Rat) (L1272)LD50: 1470 mg/kg (Subcutaneous, Mouse) (L1272)LD50: 8000 mg/kg (Intramuscular, Mouse) (L1272)
Carcinogenicity
No indication of carcinogenicity to humans (not listed by IARC).
Health effects (PubChem excerpts)
Myristicin has neurotoxic effects and hallucinogenic properties. (L1271)
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.