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    ☠ This is an extremely potent opioid active in microgram doses. Accidental overdose can be rapidly fatal. Naloxone should always be on hand.

    N-(2C)-fentanyl Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 2 corroborating sources
    • no dose data
    • 29 combo interactions documented

    Summary PsychonautWiki

    The N-(2C)-fentanyl series couples the 2C phenethylamines with the fentanyl scaffold. Reported members include N-(2C-B)-, N-(2C-C)-, N-(2C-D)-, N-(2C-E)-, N-(2C-G)-, N-(2C-H)-, N-(2C-I)-, N-(2C-IP)-, N-(2C-N)-, N-(2C-P)-, N-(2C-T)-, N-(2C-T-2)-, N-(2C-T-4)-, N-(2C-T-7)- and N-(2C-TFM)-fentanyl. No human dose, duration or effect data exists for any of them; the profile shown below is class-typical for opioids, not observation of these compounds.

    Effect Profile

    class estimate

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • No reports exist for this substance. Its effect list is the one shared by 7 other substances of the same class, so the scores below describe the class, not this compound.
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 5.1
    Moderate+ 5/10

    Strong euphoria with moderate itching/nausea, mild sedation

    Euphoria / Warmth ×3
    9
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    5
    sedation muscle relaxation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.

    No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

    Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

    Effects

    Positive
    Negative
    Neutral
    Positive
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    Neutral

    Combinations

    Cross-Check N-(2C)-fentanyl with another substance

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