N-Desethylisotonitazene
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 29 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 29 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Summary
N-Desethylisotonitazene is a depressant opioid. Reported effects include euphoria, anxiety suppression, muscle relaxation, and compulsive redosing. Limited data is available on its dosage and safety profile.
Dose Information
Dose basis. No human dose is established for N-desethylisotonitazene. A previous version of this page carried a numeric dose ladder that was wrong by roughly one to two orders of magnitude in the dangerous direction. It was removed on 7 August 2026 rather than replaced, because the defensible corrections span a 15-fold range and publishing a precise number we cannot source is the error that caused the problem. Animal data place it at roughly fentanyl-equivalent to twice fentanyl. It is a nitazene: fentanyl test strips DO NOT detect it, naloxone works but repeat doses are commonly required, and it is active in micrograms.
Effect Profile
class estimateScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- No reports exist for this substance. Its effect list is the one shared by 7 other substances of the same class, so the scores below describe the class, not this compound.
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate itching/nausea, mild sedation
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Effects
Effect glossary — · full glossary
Combinations
Cross-Check N-Desethylisotonitazene with another substanceHelpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for N-Desethylisotonitazene? Let us know. Reports are reviewed by moderators — this is not posted publicly.