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    Disclaimer
    ☠ Nitazene-class opioids are extremely potent, often exceeding fentanyl in strength. Even trace amounts can be fatal. Fentanyl test strips do NOT detect nitazenes — a negative strip does not rule one out. Naloxone works, but often needs repeated doses, and re-sedation can follow once it wears off: call emergency services and stay with the person.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    N-Desethylisotonitazene Limited data
    Limited data
    Sparse data. Doses and effects may be unreliable or untested.
    • 2 corroborating sources
    • 19 combo interactions documented
    • dose data not in PW/TripSit (unverifiable)

    Depressant Opioid

    Summary

    N-Desethylisotonitazene is a depressant opioid. Reported effects include euphoria, anxiety suppression, muscle relaxation, and compulsive redosing. Limited data is available on its dosage and safety profile.

    Dose Information PsychonautWiki

    Dose basis. No human dose is established for N-desethylisotonitazene. A previous version of this page carried a numeric dose ladder that was wrong by roughly one to two orders of magnitude in the dangerous direction. It was removed on 7 August 2026 rather than replaced, because the defensible corrections span a 15-fold range and publishing a precise number we cannot source is the error that caused the problem. Animal data place it at roughly fentanyl-equivalent to twice fentanyl. It is a nitazene: fentanyl test strips DO NOT detect it, naloxone works but repeat doses are commonly required, and it is active in micrograms.

    Effect Profile

    class estimate

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • No reports exist for this substance. Its effect list is the one shared by 8 other substances of the same class, so the scores below describe the class, not this compound.
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 5.1
    Moderate+ 5/10

    Strong euphoria with moderate itching/nausea, mild sedation

    Euphoria / Warmth ×3
    9
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    0
    Sedation / Relaxation ×1
    5
    sedation muscle relaxation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    PsychonautWiki N-Desethylisotonitazene
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects

    Positive
    • Physical euphoria
    • Muscle relaxation
    • Anxiolytic
    Negative
    • Motor impairment
    • Nausea
    • Respiratory depression
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Itchiness
    Positive
    • Reduced anxiety
    • Anxiety suppression
    • Cognitive euphoria
    • Euphoria
    Negative
    • Dizziness
    • Compulsive redosing
    • Amnesia
    • Thought deceleration
    • Motor control loss
    • Constipation
    Positive
    • Increased music appreciation
    • Increased libido
    Negative
    • Disinhibition
    • Appetite suppression
    • Dehydration
    • Light sensitivity
    • Double vision
    • Acuity suppression
    Neutral
    • Dulled perception
    • Internal hallucinations

    Combinations

    Cross-Check N-Desethylisotonitazene with another substance

    N-Desethylisotonitazene's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 PsychonautWiki