Ever since I was twelve years old I have loved drugs. Name a drug an I've done It and I've loved it. I've never come across a drug I did not like. My first love was Mary Jane, then it was LSD, next it was Benzos, and after that It was any thing that got me high. I've done it all.
Naltrexone
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 1 ROA with full dose ladder
- 19 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- dose ladder unverifiable and undisclosed — capped
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 1 ROA with full dose ladder
- 19 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
- dose ladder unverifiable and undisclosed — capped
Aliases: Revia, Depade, Trexan, Nalorex, Vivitrol
Summary
Naltrexone is an opiate antagonist used in the treatment of opiate and alcohol addiction. It blocks the effects of opiates so that if a user chooses to take an opiate after taking naltrexone, they do not experience much, if any, effect. This helps improve abstinence in those who can maintain taking the daily dose of naltrexone.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1.5-4.5mg | 25-50mg | 50-100mg | 100mg+ |
Light
Common
Strong
Heavy
Effect Profile
15 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
5.1
Moderate+
5/10
Strong euphoria with moderate itching/nausea, mild sedation
Euphoria / Warmth
×3
9
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
0
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Naltrexone there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "Naltrexone (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
Naltrexone
Unit
mg
Description
Naltrexone Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 1.5 · light 1.5-4.5 · common 25-50 · strong 50-100 · heavy 100+ Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 37.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 15 Erowid experience reports
Positive Effects 5
Stimulation
53.3%
70%
Anxiety Suppression
40.0%
70%
Body High
20.0%
70%
Empathy
20.0%
70%
Tactile Enhancement
20.0%
70%
Adverse Effects 3
Nausea
53.3%
70%
Sweating
26.7%
70%
Confusion
20.0%
70%
Combinations
Cross-Check Naltrexone with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 6 reports 2 neutral 4 cautionary visit
In this report I will detail my experience taking 4.5 mg naltrexone (known as low-dose naltrexone) nightly for psychiatric purposes. First, the background information. I have a diagnosis of bipolar 2 disorder and general anxiety disorder.
I took .1 mg clonidine at 9 AM and 15 mg (1/4 full dose) naltrexone at 930 AM. This is my first time taking Naltrexone ever. I'm an alcoholic and I've been sober for three days. Naltrexone was prescribed to me for the purpose of preventing a relapse.
I am titling this message, not to be confused with Suboxone for the simple reason it SHOULD NOT. I have been taking all types of painkillers now for years and years. I have never felt the need for help because I had never had a withdrawal from Opiates until recently. Oxycontin is my demon.
I am an MS patient and have been interested in LDN therapy for a long time but couldn't find a neurologist to prescribe it because it still lacks 'gold standard' clinical evidence. I am also an alcoholic and was prescribed naltrexone several years ago to curb alcohol cravings.
I've been addicted to opiates on and off for the past 5 years, and because of a recent relapse I am being forced to take naltrexone. I started taking it 10 days clean, and I've been on it for 2 weeks. Naltrexone treatment has a notoriously low compliance rate, and now I understand why.
Pill Identifiers
5
known pill identifiers on record — view imprints, colors, shapes, and images
→
Naltrexone's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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