Naltrexone
Aliases: Revia, Depade, Trexan, Nalorex, Vivitrol
Summary
Naltrexone is an opiate antagonist used in the treatment of opiate and alcohol addiction. It blocks the effects of opiates so that if a user chooses to take an opiate after taking naltrexone, they do not experience much, if any, effect. This helps improve abstinence in those who can maintain taking the daily dose of naltrexone.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1.5-4.5mg | 25-50mg | 50-100mg | 100mg+ |
Light
Common
Strong
Heavy
Effect Profile
15 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
5.1
Moderate+
5/10
Strong euphoria with moderate itching/nausea, mild sedation
Euphoria / Warmth
×3
9
physical euphoria
cognitive euphoria
euphoria
Analgesia
×2
0
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Effects
Aggregated from 15 Erowid experience reports
Positive Effects 5
Stimulation
53.3%
70%
Anxiety Suppression
40.0%
70%
Body High
20.0%
70%
Empathy
20.0%
70%
Tactile Enhancement
20.0%
70%
Adverse Effects 3
Nausea
53.3%
70%
Sweating
26.7%
70%
Confusion
20.0%
70%
Combinations
Pill Identifiers
5
known pill identifiers on record — view imprints, colors, shapes, and images
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Naltrexone's nerd page
Pharmacology, chemical data, effect profiles, and more
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