NDP
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Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: N-desethyl protonitazene, N-desethyl-protonitazene, N-desethylprotonitazene, Desethyl-protonitazene
Summary
NDP is a synthetic opioid of the benzimidazole class, acting as a central nervous system depressant, and is encountered as a research chemical. CFSRE measured it at roughly 2.5 times the potency of fentanyl by ฮผ-opioid EC50 โ less potent than protonitazene or N-desethylisotonitazene. A widely repeated community claim of "20x fentanyl" is not supported by any measurement. User reports describe pronounced sedation with muted euphoria and an unpleasant "dirty" body load. Analytical alerts highlight frequent misrepresentation in yellow powders sold as ketamine or in pressed pills.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. This is a microgram-active opioid: a normal milligram scale cannot weigh a dose of it accurately, and a weighing error here is measured in lethal multiples rather than percentages. Volumetric dosing is the only defensible method, and batch-to-batch potency in the unregulated supply varies enormously. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-40ยตg | 40-60ยตg | 60-80ยตg | 80ยตg+ |
| Insufflated | 2.5-5ยตg | 5-10ยตg | 10-20ยตg | 20ยตg+ |
Sources
Oral
Dose ladder — Drugs.WikiInsufflated
Dose ladder — Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-30 min | 30 min | 1-3 hrs | 1.75-4 hrs |
| Insufflated | 5-15 min | 30 min | 1-3 hrs | 1.58-3.75 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and pain relief with strong itching/nausea, mild sedation
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin ยท National Harm Reduction Coalition ยท WHO: opioid overdose ยท Merrall et al. 2010 ยท Binswanger et al. 2007 ยท Strang et al. 2003 ยท FDA 2019: gabapentinoids and breathing
Cross-Tolerances
Effects
Effect glossary — · full glossary
Combinations
Cross-Check NDP with another substanceHelpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track NDP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
NDP Source: SubstanceSearch (substancesearch.com) Oral dose (ยตg): threshold 10-20 ยท light 20-40 ยท common 40-60 ยท strong 60-80 ยท heavy 80+ Insufflated dose (ยตg): light 2.5-5 ยท common 5-10 ยท strong 10-20 ยท heavy 20+ Oral duration: onset 15-30m ยท peak 30m ยท offset 1-3h ยท total 1.75-4h ยท after-effects 2-4h Insufflated duration: onset 5-15m ยท peak 30m ยท offset 1-3h ยท total 1.58-3.75h ยท after-effects 2-4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 50 ยตg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for NDP? Let us know. Reports are reviewed by moderators — this is not posted publicly.