NDP
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- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: N-desethyl protonitazene, N-desethyl-protonitazene, N-desethylprotonitazene, Desethyl-protonitazene
Summary
NDP is a synthetic opioid of the benzimidazole class, acting as a central nervous system depressant, and is encountered as a research chemical. CFSRE measured it at roughly 2.5 times the potency of fentanyl by ΞΌ-opioid EC50 β less potent than protonitazene or N-desethylisotonitazene. A widely repeated community claim of "20x fentanyl" is not supported by any measurement. User reports describe pronounced sedation with muted euphoria and an unpleasant "dirty" body load. Analytical alerts highlight frequent misrepresentation in yellow powders sold as ketamine or in pressed pills.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. This is a microgram-active opioid: a normal milligram scale cannot weigh a dose of it accurately, and a weighing error here is measured in lethal multiples rather than percentages. Volumetric dosing is the only defensible method, and batch-to-batch potency in the unregulated supply varies enormously. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-40Β΅g | 40-60Β΅g | 60-80Β΅g | 80Β΅g+ |
| Insufflated | 2.5-5Β΅g | 5-10Β΅g | 10-20Β΅g | 20Β΅g+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-30 min | 30 min | 1-3 hrs | 1.75-4 hrs |
| Insufflated | 5-15 min | 30 min | 1-3 hrs | 1.58-3.75 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria, itching/nausea, and pain relief with mild sedation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track NDP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
NDP Source: SubstanceSearch (substancesearch.com) Oral dose (Β΅g): threshold 10-20 Β· light 20-40 Β· common 40-60 Β· strong 60-80 Β· heavy 80+ Insufflated dose (Β΅g): threshold 2.5-5 Β· light 2.5-5 Β· common 5-10 Β· strong 10-20 Β· heavy 20+ Oral duration: onset 15-30m Β· peak 30m Β· offset 1-3h Β· total 1.75-4h Β· after-effects 2-4h Insufflated duration: onset 5-15m Β· peak 30m Β· offset 1-3h Β· total 1.58-3.75h Β· after-effects 2-4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 50 Β΅g (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Opioid crossβtolerance is expected; nitazene tolerance can escalate rapidly with daily use. Data are largely anecdotal; exact rates of tolerance development and decay for NDP are unknown. Avoid daily use; long washout periods reduce accumulation risk.
Cross-Tolerances
Effects
- Physical euphoria
- Pain relief
- Muscle relaxation
- Analgesia
- Respiratory depression
- Nausea
- Itching
- Sedation
- Itchiness
- Pupil constriction
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Euphoria
- Constipation
- Compulsive redosing
- Motivation suppression
- Anxiety
- Warmth
- Increased music appreciation
- Increased libido
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Dulled perception
- Warm flush
- Internal hallucination
Combinations
Cross-Check NDP with another substanceHelpful Links
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