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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    NDP Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    NDP is a synthetic opioid of the benzimidazole class, acting as a central nervous system depressant, and is encountered as a research chemical. One known source in the RC community claims that its potency is 20x stronger than fentanyl. User reports describe pronounced sedation with muted euphoria and an unpleasant "dirty" body load. Analytical alerts highlight frequent misrepresentation in yellow powders sold as ketamine or in pressed pills.

    Dose Information TheDrug.Wiki

    ROA Light Common Strong Heavy
    Oral 20-40µg 40-60µg 60-80µg 80µg+
    Insufflated 2.5-5µg 5-10µg 10-20µg 20µg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 15-30 min 0.5-2 hrs 1-3 hrs 2-4 hrs 3-6 hrs
    Insufflated 5-15 min 0.5-2 hrs 1-3 hrs 2-4 hrs 3-6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 7.3
    Strong+ 7/10

    Strong euphoria, itching/nausea, and pain relief with mild sedation

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria warmth
    Analgesia ×2
    8
    pain relief analgesia
    Sedation / Relaxation ×1
    5
    sedation muscle relaxation
    ⚠ Itching / Nausea ×1
    10
    itching nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki NDP
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~28d

    Opioid cross‑tolerance is expected; nitazene tolerance can escalate rapidly with daily use. Data are largely anecdotal; exact rates of tolerance development and decay for NDP are unknown. Avoid daily use; long washout periods reduce accumulation risk.

    Cross-Tolerances

    Fentanyl analogues
    70%
    Other nitazenes
    80%
    Morphine‑class opioids
    60%

    Effects TheDrug.Wiki

    Positive
    • Physical euphoria
    • Pain relief
    • Muscle relaxation
    • Analgesia
    Negative
    • Respiratory depression
    • Nausea
    • Itching
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Reduced anxiety
    • Wakefulness
    • Motivation enhancement
    • Euphoria
    Negative
    • Constipation
    • Compulsive redosing
    • Motivation suppression
    • Anxiety
    Positive
    • Warmth
    • Increased music appreciation
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Dulled perception
    • Warm flush
    • Internal hallucination

    Combinations TripSit

    Cross-Check NDP with another substance

    NDP's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki