Nimetazepam Stats & Data
GWUSZQUVEVMBPI-UHFFFAOYSA-NPharmacology
DrugBankReceptor Profile
Receptor Actions
Toxicity
PubChemBenzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor.
Carcinogenicity
No indication of carcinogenicity to humans (not listed by IARC).
Effect Profile
Curated + 4 ReportsStrong anxiolysis, cognitive impairment, and euphoria with moderate sedation
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Benzodiazepine tolerance to hypnotic/anxiolytic effects can develop within days to weeks of regular use and decays over weeks with abstinence. Cross‑tolerance across benzodiazepines is expected due to shared GABA(A) positive allosteric modulation; magnitude varies among compounds. Data specific to nimetazepam are limited; figures above are a pragmatic harm‑reduction model rather than clinical PK/PD estimates.
Cross-Tolerances
Experience Report Analysis
ErowidDemographics
Gender Distribution
Age Distribution
Reports Over Time
Effect Analysis
ErowidEffects aggregated from 4 experience reports (4 Erowid)
Effect Sentiment Distribution
Confidence Distribution
Positive Effects 1
Adverse Effects 0
Real-World Dose Distribution
62K DosesFrom 5 individual dose entries
Legal Status
| Country | Status | Notes |
|---|---|---|
| Hong Kong | regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance | |
| Singapore | physician prescribed drug, and is regulated under the Misuse of Drugs Act | |
| United States | categorized Schedule IV FDA and DEA |
Harm Reduction
drugs.wikiNimetazepam is marketed mainly in parts of Asia (e.g., as 5 mg 'Erimin 5'); non-medical availability often involves counterfeit tablets that may contain other benzodiazepines, making potency unpredictable—assume unknown composition and avoid mixed-source pills unless lab-checked. Next‑day sedation, impaired coordination, and memory gaps are common with long/medium-acting benzodiazepines; avoid driving or operating machinery until at least the day after use and longer if residual effects are present. Combining benzodiazepines with opioids, alcohol, GHB/GBL, or other depressants greatly increases the risk of life‑threatening respiratory depression and fatal overdose; avoid co‑use and never use alone. Tolerance develops quickly with repeated use and can encourage escalation; spacing uses by weeks and avoiding consecutive‑night dosing reduces risk of rapid tolerance. Abrupt cessation after sustained use can cause severe withdrawal (anxiety, insomnia, agitation, tremor, seizures); any taper should be slow and medically supervised. 'Blackout' amnesia can lead to unintentional redosing—pre‑measure a single dose, keep a log, and have a trusted sober person hold the supply if needed. Crushing or injecting tablets is dangerous due to insoluble binders/fillers (risk of vein damage, infection) and unpredictable kinetics; stick to oral use only. People who are pregnant can produce neonates with benzodiazepine withdrawal symptoms; discuss any exposure with a clinician. Older adults and those with renal or general frailty have heightened sensitivity to sedation and falls; lower thresholds and longer spacing are prudent. Reports note nimetazepam may partially metabolise to nitrazepam and has high oral bioavailability with relatively rapid onset—this can increase misuse potential; extra caution with redosing is warranted. In unregulated markets, prioritize drug checking where available; if not, avoid brand‑dependent assumptions (e.g., 'Erimin 5' logo) as authenticity is unreliable.
References
Data Sources
Cited References
Drugs.wiki References
- Erowid Nimetazepam (Erimin) Vault — names/availability overview
- TripSit Wiki — Uncommon Benzodiazepines (nimetazepam BA, onset ≈30 min, mean half‑life 14–30 h; partial metabolism to nitrazepam)
- PubChem — Nimetazepam compound entry (identity/structure)
- EUDA (EMCDDA) European Drug Report/Overdose risk — benzodiazepines commonly present in fatal overdoses, especially with opioids
- EUDA — Risk factors (polydrug depressant use: opioids + benzodiazepines)
- DrugWise — Benzodiazepines (withdrawal dangers, driving risk, harm‑reduction advice)
- Hi‑Ground — Benzos page (unsafe combinations incl. opioids, alcohol, GHB/GBL, tramadol, ketamine; caution with antipsychotics/antihistamines)
- SubstanceSearch — Nimetazepam alias and rough timing (community HR repository)
- Bluelight — 'Happy 5' / counterfeit 'Erimin 5' discussion (counterfeit prevalence; harm‑reduction context)