Nimetazepam
Aliases: Lavol, Erimin, Hypnon, Happy 5, Erimin-5
Summary
Nimetazepam is a potent intermediate-acting benzodiazepine with rapid onset and high abuse potential. It is primarily prescribed in Asia for severe insomnia and as an anticonvulsant in children. The drug has near 100% oral bioavailability and is the N-methylated analogue of nitrazepam, to which it partially metabolizes.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2.5-5mg | 5-10mg | 10-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 1-4 hrs | 4-8 hrs | 5.8-13.5 hrs |
Effect Profile
4 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiolysis, cognitive impairment, and euphoria with moderate sedation
Tolerance
Tolerance Decay
Benzodiazepine tolerance to hypnotic/anxiolytic effects can develop within days to weeks of regular use and decays over weeks with abstinence. Cross‑tolerance across benzodiazepines is expected due to shared GABA(A) positive allosteric modulation; magnitude varies among compounds. Data specific to nimetazepam are limited; figures above are a pragmatic harm‑reduction model rather than clinical PK/PD estimates.
Cross-Tolerances
Effects
Aggregated from 4 Erowid experience reports