Summary
Nimetazepam is a potent intermediate-acting benzodiazepine with rapid onset and high abuse potential. It is primarily prescribed in Asia for severe insomnia and as an anticonvulsant in children. The drug has near 100% oral bioavailability and is the N-methylated analogue of nitrazepam, to which it partially metabolizes. Street tablets sold as Erimin-5 are frequently counterfeit and may contain other benzodiazepines. Commonly misused to soften stimulant comedowns or as an MDMA/heroin substitute.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2.5-5mg | 5-10mg | 10-20mg | 20mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 1-4 hrs | 4-8 hrs | 12-24 hrs | 300-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Muscle Relaxation
- Anxiolytic
- Muscle Relaxant
- Muscle relaxation
- Physical euphoria
Negative
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety Suppression
- Euphoria
- Anxiety suppression
Negative
- Amnesia
- Motor Control Loss
- Dream Suppression
- Thought Deceleration
- Cognitive Impairment
- Motor control loss
- Dizziness
Positive
- Increased libido
- Appetite enhancement
Negative
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Acuity Suppression
- Decreased Libido
- Double vision
- Dulled perception
- Perception of bodily heaviness