Effect Profile
Curated + 2 ReportsStrong dissociative depth and motor impairment with moderate mania, mild insight
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Anecdotal reports with arylcyclohexylamines suggest rapid acute tolerance within a session and slow decay over 2–4+ weeks; spacing multi‑week intervals helps restore baseline response.
Cross-Tolerances
Experience Report Analysis
ErowidDemographics
Gender Distribution
Age Distribution
Reports Over Time
Harm Reduction
drugs.wikiIdentity and naming: O‑PCPr is 2′‑Oxo‑PCPr (2‑keto‑PCPr), an arylcyclohexylamine closely related to O‑PCE and PCP analogs; community threads reported it emerging after late‑2024 mislabeling as O‑PCE/O‑PCP. Mislabeling is common in this class—use drug checking and perform an allergy test before any psychoactive dose. Community reports describe a short‑to‑moderate duration dissociative with heavy body load, motor incoordination, and intermittent euphoria; sensitivity varies widely, so start low and wait a full onset window (at least 60–120 minutes oral, 45–60 minutes IN) before considering any redose. Dissociatives can aggravate lower urinary tract symptoms; ketamine‑like urological complications (including cystitis) are dose/frequency‑related—prioritize spacing (≥2–4 weeks), hydration, and early cessation if urinary discomfort, urgency, or pain occurs. Combining dissociatives with other CNS depressants (alcohol, benzos, GHB/GBL) markedly increases risks of blackout, aspiration, and accidents; stimulants raise cardiovascular strain and can precipitate agitation or manic states; avoid tramadol due to seizure risk and serotonergic complications. Use precise measurement: 0.001 g scales and volumetric dosing reduce dosing error and support allergy testing (e.g., ≤1 mg) when a lab result is unavailable. Expect impaired coordination and lingering fog; do not drive or perform safety‑critical tasks until fully baseline the next day. Market reports have noted bladder irritation and supply confusion (e.g., O‑PCE or O‑PCP sold instead); reagent tests are insufficient—seek lab‑based drug checking where available.
References
Drugs.wiki References
- Dissociatives – The Small and Handy O‑PCPr thread (Bluelight)
- O‑PCPr, 90 mg IN – Heavy euphoria in the dissociative breeze (Bluelight trip report)
- O‑PCPr Trip Report – Oral 50 mg (Reddit)
- Report: Novel dissociative O‑PCPr (Reddit)
- 2′‑Oxo‑PCPr (PiHKAL·info / IsomerDesign)
- O‑PCP mislabeling discussion (Bluelight)
- Saferparty Zürich – 2‑Oxo‑PCE sold as Ketamine (mislabeling warning)
- TripSit – Drug combinations (MXE/DXM sections as dissociative class guidance)
- TripSit – Ketamine (bladder and dependence cautions)
- Erowid – Ketamine FAQ (tolerance often requires weeks)
- Erowid – KLUTS: Ketamine & Lower Urinary Tract Symptoms
- EUDA European Drug Report – Other drugs (ketamine harms incl. urological complications)
- Drug Users Bible – 10 Commandments of Safer Drug Use (scales & volumetric dosing; allergy test)