[Please note: I have developed a dissociative tolerance and I also prefer strong experiences. This is a massive dose for a normal person. For someone without a tolerance I would suggest starting at 20 mg for this compound.
O-PCPr
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 2'-oxo-pcpr, Deschloro-n-propyl-ketamine
Summary
O-PCPr emerged in late 2024 after being mis-sold as O-PCE. User reports describe a steep dose-response curve, rapid onset with upwellings of euphoria, pronounced motor incoordination, bright closed-eye visuals, and a warm euphoria distinct from MXiPr or O-PCE. The headspace is relatively lucid and functional compared to other dissociatives.
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
Dose basis. Dose ranges reflect early user reports; highly variable sensitivity and frequent mislabeling in this class necessitate allergy testing and volumetric dosing. Nasal use may be irritating and increases compulsive redosing risk; start at the low end and wait full onset before re-dosing. Data quality: anecdotal forum reports. Oral onset is slower but effects may feel smoother and last longer. Use precise measurement; allergy-test first due to mislabeling risk in the supply. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 10-20mg | 20-40mg | 40-70mg | 70mg+ |
| Oral | 25-45mg | 45-70mg | 70-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 5-15 min | 10-20 min | 1-3 hrs | 2-4 hrs | 3.25-7.58 hrs |
| Oral | 30-60 min | 30-60 min | 1-3 hrs | 2-4 hrs | 4-9 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.3
Strong
6/10
Strong dissociative depth and motor impairment with moderate mania, mild insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
spatial disorientation
+2 more
Mania / Compulsion
×1
6
disinhibition
stimulation
euphoria
Insight / Novel Thought
×2
5
conceptual thinking
analysis enhancement
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
+1 more
Based on reports from:
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track O-PCPr there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "O-PCPr (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
O-PCPr
Unit
mg
Description
O-PCPr Source: SubstanceSearch (substancesearch.com) Insufflated dose (mg): threshold 5-10 · light 10-20 · common 20-40 · strong 40-70 · heavy 70+ Oral dose (mg): threshold 15-25 · light 25-45 · common 45-70 · strong 70-100 · heavy 100+ Insufflated duration: onset 5-15m · come-up 10-20m · peak 1-3h · offset 2-4h · total 3.25-7.58h · after-effects 1-4h Oral duration: onset 0.5-1h · come-up 0.5-1h · peak 1-3h · offset 2-4h · total 4-9h · after-effects 1-4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 30 mg (Insufflated).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
14d
Baseline
~21d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Anecdotal reports with arylcyclohexylamines suggest rapid acute tolerance within a session and slow decay over 2–4+ weeks; spacing multi‑week intervals helps restore baseline response.
Cross-Tolerances
Effects
Positive
- Analgesia
- Physical euphoria
- Stimulation
- Pain relief
Negative
- Numbness
- Loss of balance
- Nausea
- Physical disconnection
- Suggestibility enhancement
- Sedation
Positive
- Euphoria
- Conceptual thinking
- Analysis enhancement
- Cognitive euphoria
Negative
- Cognitive disconnection
- Motor control loss
- Amnesia
- Depersonalization
- Derealization
- Time distortion
Positive
- Perception of bodily lightness
- Increased music appreciation
- Tactile enhancement
Negative
- Spatial disorientation
- Tactile suppression
- Disinhibition
- Double vision
- Visual disconnection
- Internal hallucination
- Auditory distortion
Combinations
Cross-Check O-PCPr with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 1 positive 1 neutral visit
I have had the pleasure of being able to try the novel compound O-PCPr recently and was extremely surprised by what I experienced. After seeing this compound for sale and reading the report made by the great dissociative enthusiast nervewing, I had to follow in their footsteps to try this one and write out at least one...
O-PCPr's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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