[Please note: I have developed a dissociative tolerance and I also prefer strong experiences. This is a massive dose for a normal person. For someone without a tolerance I would suggest starting at 20 mg for this compound.
O-PCPr
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 2'-oxo-pcpr, Deschloro-n-propyl-ketamine
Summary
O-PCPr emerged in late 2024 after being mis-sold as O-PCE. User reports describe a steep dose-response curve, rapid onset with upwellings of euphoria, pronounced motor incoordination, bright closed-eye visuals, and a warm euphoria distinct from MXiPr or O-PCE. The headspace is relatively lucid and functional compared to other dissociatives.
Dose Information
Dose basis. Insufflated: Dose ranges reflect early user reports; highly variable sensitivity and frequent mislabeling in this class necessitate allergy testing and volumetric dosing. Nasal use may be irritating and increases compulsive redosing risk; start at the low end and wait full onset before re-dosing. Data quality: anecdotal forum reports. Oral: Oral onset is slower but effects may feel smoother and last longer. Use precise measurement; allergy-test first due to mislabeling risk in the supply. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 10-20mg | 20-40mg | 40-70mg | 70mg+ |
| Oral | 25-45mg | 45-70mg | 70-100mg | 100mg+ |
Light
Common
Strong
Heavy
Sources
Insufflated
Dose ladder — Drugs.WikiOral
Dose ladder — Drugs.WikiOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Insufflated | 5-15 min | 10-20 min | 1-3 hrs | 2-4 hrs | 3.25-7.58 hrs |
| Oral | 30-60 min | 30-60 min | 1-3 hrs | 2-4 hrs | 4-9 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.3
Strong
6/10
Strong dissociative depth with strong motor impairment, moderate mania, mild insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
spatial disorientation
+2 more
Mania / Compulsion
×1
6
disinhibition
stimulation
euphoria
Insight / Novel Thought
×2
5
conceptual thinking
analysis enhancement
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
+1 more
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
14d
Baseline
~21d
Anecdotal reports with arylcyclohexylamines suggest rapid acute tolerance within a session and slow decay over 2–4+ weeks; spacing multi‑week intervals helps restore baseline response.
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check O-PCPr with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 1 positive 1 neutral visit
I have had the pleasure of being able to try the novel compound O-PCPr recently and was extremely surprised by what I experienced. After seeing this compound for sale and reading the report made by the great dissociative enthusiast nervewing, I had to follow in their footsteps to try this one and write out at least one...
O-PCPr's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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The PsychonautWiki Journal logging app doesn't include every substance. To track O-PCPr there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "O-PCPr (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
O-PCPr
Unit
mg
Description
O-PCPr Source: SubstanceSearch (substancesearch.com) Insufflated dose (mg): threshold 5-10 · light 10-20 · common 20-40 · strong 40-70 · heavy 70+ Oral dose (mg): threshold 15-25 · light 25-45 · common 45-70 · strong 70-100 · heavy 100+ Insufflated duration: onset 5-15m · come-up 10-20m · peak 1-3h · offset 2-4h · total 3.25-7.58h · after-effects 1-4h Oral duration: onset 0.5-1h · come-up 0.5-1h · peak 1-3h · offset 2-4h · total 4-9h · after-effects 1-4h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 30 mg (Insufflated).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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