[Please note: I have developed a dissociative tolerance and I also prefer strong experiences. This is a massive dose for a normal person. For someone without a tolerance I would suggest starting at 20 mg for this compound.
O-PCPr
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 2 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 2'-oxo-pcpr, Deschloro-n-propyl-ketamine
Summary
O-PCPr emerged in late 2024 after being mis-sold as O-PCE. User reports describe a steep dose-response curve, rapid onset with upwellings of euphoria, pronounced motor incoordination, bright closed-eye visuals, and a warm euphoria distinct from MXiPr or O-PCE. The headspace is relatively lucid and functional compared to other dissociatives.
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 10-20mg | 20-40mg | 40-70mg | 70mg+ |
| Oral | 25-45mg | 45-70mg | 70-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Insufflated | 5-15 min | 1-3 hrs | 2-4 hrs | 5-9 hrs |
| Oral | 30-60 min | 1-3 hrs | 2-4 hrs | 5-9 hrs |
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Dissociative
6.3
Strong
6/10
Strong dissociative depth and motor impairment with moderate mania, mild insight
Dissociative Depth
×3
10
depersonalization
derealization
physical disconnection
cognitive disconnection
visual disconnection
spatial disorientation
+2 more
Mania / Compulsion
×1
6
disinhibition
stimulation
euphoria
Insight / Novel Thought
×2
5
conceptual thinking
analysis enhancement
Motor / Sensory Impairment
×1
10
motor control loss
physical disconnection
tactile suppression
numbness
spatial disorientation
visual disconnection
+1 more
Based on reports from:
Tolerance
Build-up
develops with repeated use over days to weeks
Reset
2–4 weeks for noticeable reduction
Tolerance Decay
Full tolerance
1d
Half tolerance
14d
Baseline
~21d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Anecdotal reports with arylcyclohexylamines suggest rapid acute tolerance within a session and slow decay over 2–4+ weeks; spacing multi‑week intervals helps restore baseline response.
Cross-Tolerances
Effects
Positive
- Analgesia
- Physical euphoria
- Stimulation
- Pain relief
Negative
- Numbness
- Loss of balance
- Nausea
- Physical disconnection
- Suggestibility enhancement
- Sedation
Positive
- Euphoria
- Conceptual thinking
- Analysis enhancement
- Cognitive euphoria
Negative
- Cognitive disconnection
- Motor control loss
- Amnesia
- Depersonalization
- Derealization
- Time distortion
Positive
- Perception of bodily lightness
- Increased music appreciation
- Tactile enhancement
Negative
- Spatial disorientation
- Tactile suppression
- Disinhibition
- Double vision
- Visual disconnection
- Internal hallucination
- Auditory distortion
Combinations
Cross-Check O-PCPr with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 2 reports 2 neutral visit
I have had the pleasure of being able to try the novel compound O-PCPr recently and was extremely surprised by what I experienced. After seeing this compound for sale and reading the report made by the great dissociative enthusiast nervewing, I had to follow in their footsteps to try this one and write out at least one...
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Pharmacology, chemical data, effect profiles, and more
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