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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    O-PCPr

    Aliases: 2'-oxo-pcpr, Deschloro-n-propyl-ketamine

    Dissociative Research-chemical

    Summary TheDrug.Wiki

    O-PCPr emerged in late 2024 after being mis-sold as O-PCE. User reports describe a steep dose-response curve, rapid onset with upwellings of euphoria, pronounced motor incoordination, bright closed-eye visuals, and a warm euphoria distinct from MXiPr or O-PCE. The headspace is relatively lucid and functional compared to other dissociatives.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Insufflated 5-15 min 10-20 min 1-3 hrs 2-4 hrs 1-4 hrs
    Oral 30-60 min 30-60 min 1-3 hrs 2-4 hrs 1-4 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 6.3
    Strong 6/10

    Strong dissociative depth and motor impairment with moderate mania, mild insight

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection cognitive disconnection visual disconnection spatial disorientation +2 more
    ⚠ Mania / Compulsion ×1
    6
    disinhibition stimulation euphoria
    Insight / Novel Thought ×2
    5
    conceptual thinking analysis enhancement
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Based on reports from:
    Erowid Experience Reports PsychonautWiki O-PCPr
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2–4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~21d

    Anecdotal reports with arylcyclohexylamines suggest rapid acute tolerance within a session and slow decay over 2–4+ weeks; spacing multi‑week intervals helps restore baseline response.

    Cross-Tolerances

    Ketamine
    50%
    O-PCE
    50%
    3-MeO-PCP and PCP analogs
    50%

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    • Physical euphoria
    • Stimulation
    • Pain relief
    Negative
    • Numbness
    • Loss of balance
    • Nausea
    Neutral
    • Physical disconnection
    • Suggestibility enhancement
    • Sedation
    Positive
    • Euphoria
    • Conceptual thinking
    • Analysis enhancement
    • Cognitive euphoria
    Negative
    • Cognitive disconnection
    • Motor control loss
    • Amnesia
    • Depersonalization
    • Derealization
    Neutral
    • Time distortion
    Positive
    • Perception of bodily lightness
    • Increased music appreciation
    • Tactile enhancement
    Negative
    • Spatial disorientation
    • Tactile suppression
    • Disinhibition
    • Double vision
    Neutral
    • Visual disconnection
    • Internal hallucination
    • Auditory distortion

    Combinations TripSit

    O-PCPr's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki