Summary
Community reports describe near-complete termination of LSD or psilocybin effects within ~30 min after a 5-10 mg orally-disintegrating dose, usually followed by deep sleep. Controlled studies show a single 10 mg IM injection quells acute agitation as effectively as haloperidol but with fewer extrapyramidal reactions. Orally-disintegrating formulations dissolve in under one minute and reach measurable plasma levels faster than standard tablets. Mean elimination half-life is ~30 h (range 21-54 h), explaining next-day lethargy. Case reports of ingestions >40 mg document coma, miotic pupils and hypoventilation—clinical presentation that can mimic opioid toxicity—managed with airway support and monitoring.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral / Orally Disintegrating Tablet | 15-45 min | 30-60 min | 1-3 hrs | 4-8 hrs | 18-24 hrs |
| Intramuscular (Clinical Setting) | 15 min | 15-30 min | 1-3 hrs | 4-8 hrs | 18-24 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Anxiolysis
- Stimulation
- Pain Relief
- Physical Euphoria
Negative
- Dry mouth
- Motor impairment
- Sweating
- Powerful sedation
- Sedation
- Itchiness
Positive
- Reduced anxiety
- Anxiety suppression
Negative
- Motor control loss
- Constipation
- Emotion suppression
- Thought deceleration
- Dizziness
- Emotional blunting
- Increased appetite
- Next-day grogginess
Positive
Negative
- Cognitive dysphoria
- Light sensitivity
- Disinhibition
- Appetite Suppression
- Decreased Libido
- Orgasm Suppression
- Acuity Suppression
- Appetite suppression
- Dulled perception
- Increased sexuality