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    Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Olanzapine Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data

    Aliases: Lanzac, Zyprexa, Olansek, Symbyax, Olanzapin

    Summary TheDrug.Wiki Erowid

    Community reports describe near-complete termination of LSD or psilocybin effects within ~30 min after a 5-10 mg orally-disintegrating dose, usually followed by deep sleep. Controlled studies show a single 10 mg IM injection quells acute agitation as effectively as haloperidol but with fewer extrapyramidal reactions. Orally-disintegrating formulations dissolve in under one minute and reach measurable plasma levels faster than standard tablets.

    Dose Information TheDrug.Wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral BA 60 65% 2.5-5mg 5-10mg 10-15mg 15mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral / Orally Disintegrating Tablet 15-45 min 30-60 min 1-3 hrs 4-8 hrs 18-24 hrs -
    Intramuscular (Clinical Setting) 15 min 15-30 min 1-3 hrs 4-8 hrs 18-24 hrs -
    Oral 40-60 min - 1.5-6 hrs 8-12 hrs 20-24 hrs 6-8 hrs

    Effect Profile

    60 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 60 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 4.9
    Moderate+ 5/10

    Strong sedation with moderate itching/nausea, mild euphoria and pain relief

    Euphoria / Warmth ×3
    4
    physical euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    10
    powerful sedation sedation
    Itching / Nausea ×1
    6
    constipation dry mouth sweating

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Half tolerance 7d Baseline ~35d

    With occasional use, pharmacodynamic tolerance is minimal; daily therapy over weeks leads to appreciable tolerance to sedation and other effects.

    Effects Erowid

    Aggregated from 60 Erowid experience reports

    Positive Effects 10

    Sedation 48.3% 70%
    Anxiety Suppression 40.0% 70%
    Stimulation 28.3% 70%
    Empathy 13.3% 70%
    Focus Enhancement 11.7% 70%
    Euphoria 10.0% 70%
    Body High 6.7% 70%
    Color Enhancement 5.0% 70%
    Music Enhancement 5.0% 70%
    Tactile Enhancement 5.0% 70%

    Adverse Effects 4

    Psychosis 36.7% 70%
    Confusion 15.0% 70%
    Memory Suppression 8.3% 70%
    Nausea 8.3% 70%

    Combinations TripSit

    Cross-Check Olanzapine with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 1 positive 3 neutral 4 cautionary visit
    Helping Me Sleep positive exp #65051

    I have had imsomnia ever since I can remember. As a kid, staying up till sunrise was quite fun. As an adult, its more than just a little nuisance, its an obstacle. Being on zyprexa has really helped this, and its not addictive from what I can tell.

    Evan · 20 mg oral
    Walking Through School Dreams neutral exp #64695

    I was at School one day when I asked my friend K if he had any bars (xanax) and he told me he didn't but he did pull out a bottle of pills with the name lilly 4415 on the pills during class (my school is really ghetto so SOME teachers don't really care what your doing).

    OHNO · 30 mg oral
    Couldn't Keep My Eyes Open neutral exp #35272

    I might not have been in the right mindset for this experience, nor the right setting. I had just spent the last night on caffeine, ginger root, and 150 mgs of phenylpropanolamine. Needless to say I was kind of depressed, tired, and ready for something to come over and take the edge off of the day.

    Zyprexa · Olanzapine (Zyprexa) · 10 mg oral
    Good as Medicine neutral exp #58711

    Olanzapine / Zyprexa I wouldnt say has recreational potential, but it's good as medication. When taken regularly, same time every day, for 4 weeks, it gives full effect, not like anti-depressants, its very diffirent. I feel a constant feeling of slight euphoria, it helps with anxiety, nervousness, stress etc.

    Anon · 10 mg oral
    My Psychotic Episode cautionary exp #41305

    I have been using 10mg Olanzapine a day following a psychotic episode brought on by a few bad acid and ecstasy trips that happened over a year ago now. Since then, I have been slowly working towards reintegrating myself back into normal life, and it has to be said that the Olanzapine has helped a lot.

    Oblivion · 10 mg oral
    For Bipolar II and Acute Hypomania cautionary exp #70175

    Zyprexa for Bipolar II and Acute Hypomania I'm a 21 year old male, a regular pot-smoker who occasionally uses psychedelics (few times a year). I suffer from severe depression and Bipolar II. Meth is a huge mistake for anyone, but it's a special kind of dumb to take it when you're bipolar.

    Herbivore · 2,5-5 mg oral
    Olanzapine = Sleep cautionary exp #36677

    OK, the idea to try this out surfaced from a completely rediculous assumption that it would have a sedative effect on me. I was inclined to try it after I made a girl I know (we'll just call her Gorilla Chieftain) read me the entire contents of her medicine cabinet to me on AOL instant messenger one night.

    bronto · Olanzapine (Zyprexa) · 15 mg oral
    OlanWonder Drug cautionary exp #69159

    If you're looking for a recreational drug - this is not it. However, if you suffer, or have suffered from severe depression - specifically Bipolar Depression, and have found that standard anti-depressants (SSRI's) do not work, or if you are dealing with a crisis level of anxiety, depression, mania, obsession or tempora...

    The Merry Prankster · Olanzapine (Zyprexa) · 5 mg oral
    Bluelight 1 thread 1 neutral visit
    Zyprex 15mg Abilify Vs Zyprexa neutral

    So I've been on zyprexa for about 5 months now for bipolar and it's been a miracle drug for me. I am naturally too skinny and in 4 months of taking zyprexa I gained 45 pounds and look and feel better than I have in years. Lately I've been depressed. I also take Adderall 20mgs, Klonopin, 6 mgs, and Zoloft 100mgs a day.

    scraped 2026-03-14

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