Oxytocin Limited data

Limited data

Sparse data. Doses and effects may be unreliable or untested.

1 source

no dose data

19 combo interactions documented

PubChem toxicity data

Aliases: Pitocin, Syntocinon

Summary Erowid

Oxytocin is a hormone associated with parenting and social bonding. It is released after birth in women and after orgasm in both sexes. Oxytocin is sometimes administered to facilitate labor or lactation.

Effect Profile

8 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 5.1

Moderate+ 5/10

Strong euphoria with moderate itching/nausea, mild sedation

Euphoria / Warmth ×3

physical euphoria cognitive euphoria euphoria

Analgesia ×2

Sedation / Relaxation ×1

sedation muscle relaxation

⚠ Itching / Nausea ×1

nausea constipation

Based on reports from:

Erowid Experience Reports PsychonautWiki Oxytocin

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 1d Half tolerance 21d Baseline ~35d

Effects Erowid

Aggregated from 8 Erowid experience reports

Positive Effects 2

Euphoria 37.5% 70%

Empathy 37.5% 70%

Adverse Effects 0

Combinations TripSit

Cross-Check Oxytocin with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

Erowid 5 reports 4 neutral 1 cautionary visit

Odd but Effective Analgesic neutral exp #112743

I was prescribed oxytocin for pain associated with ME/CFS, a serious chronic illness that had left me bedridden totally at the time of the experience. My pain had been so bad on and off that I was often moaning out loud for hours and biting my arm to distract myself.

Feels a Bit Like Low-Dose Iboga neutral exp #93667

Well, I never thought of trying oxytocin for myself. I figured it was for autistics and generally folks that were not the cuddly-types. I'm super cuddly, so I thought I must have lots of oxytocin. I guess the truth is I have lots of good oxytocin receptors, but not much oxytocin to fill them up.

I Felt Very Good neutral exp #110791

Oxytocin for Sex and Loving I started taking oral spray, both nostrils (10IU depending on spray or sublingual), around age 65 to enable relationships and encourage my sexuality. It worked great for both - I began an intense relationship and had extensive, deep, satisfying, passionate sexual activity.

Nasal Spray Gone Wrong neutral exp #109864

Oxytocin Gone Wrong I took two sprays in the day, two at night and two the next day as a friend had said that these sprays can help encourage connection. It has been quite the opposite for me.

Light and Happy cautionary exp #85839

Had a vial of about 100 cc or so between about three or four people, cant completely remember but it came straight from the hospital with a rubber top to poke the syringe through.

Oxytocin's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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Oxytocin Limited data Limited data Sparse data. Doses and effects may be unreliable or untested. 1 source no dose data 19 combo interactions documented PubChem toxicity data