Paracetamol
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- partial dose data
- duration data present
- PubChem toxicity data
- 3 corroborating sources
- partial dose data
- duration data present
- PubChem toxicity data
Aliases: Apap, Tylenol, Acetaminophen, Pain reliever extra strength
Summary
Acetaminophen is a non-salicylate analgesic and antipyretic (pain killer and fever reducer). It is a common over-the-counter pain medication found in hundreds of products around the world. At higher doses it is known to cause liver-damage and has a low therapeutic index (ratio of effective dose to toxic dose), making it dangerous when included in recreationally used pharmaceuticals.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | - | 200-500mg | - | - |
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Oral | 60 min | 4-6 hrs | 4-6 hrs |
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Physical euphoria
- Stimulation
- Muscle relaxation
- Spontaneous tactile sensations
- Nausea
- Increased heart rate
- Respiratory depression
- Sedation
- Difficulty urinating
- Spontaneous bodily sensations
- Euphoria
- Cognitive euphoria
- Anxiety suppression
- Wakefulness
- Anxiety
- Thought deceleration
- Dizziness
- Memory suppression
- Compulsive redosing
- Time distortion
- Increased libido
- Increased music appreciation
- Appetite suppression
- Disinhibition
- Dehydration
- Internal hallucinations
- Dulled perception
- Auditory hallucinations
- Drifting
- Auditory distortion
Pill Identifiers
Helpful Links
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