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    Pramiracetam molecular structure

    Pramiracetam Stats & Data

    Stimulant Nootropic Research-chemical
    Remen Ci-879 Pramistar Neupramir
    NPS DataHub
    MW269.39
    FormulaC14H27N3O2
    CAS68497-62-1
    IUPACN-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide
    SMILESCC(C)N(CCNC(=O)CN1CCCC1=O)C(C)C
    InChIKeyZULJGOSFKWFVRX-UHFFFAOYSA-N
    Pharmaceuticals
    Psychoactive Class Stimulant

    Pharmacology

    DrugBank

    Description

    Pramiracetam has been previously approved in some eastern European countries under the brand names Pramistar, Neupramir, and Remen. It was also previously approved in the United States with orphan drug designation . Pramiracetam has been studied for the use in Alzheimer's disease and as an adjunct treatment to restore cognitive functioning post-electroconvulsive therapy in severe depression .

    Receptor Profile

    Receptor Actions

    Other
    Enhanced high-affinity choline uptake (HACU) in the hippocampus
    increased acetylcholine synthesis
    increased nitric oxide activity (cerebral blood flow enhancement)

    Receptor Binding

    Muscarinic acetylcholine receptor M5 modulator

    Effect Profile

    Curated + 4 Reports
    Stimulant 5.5

    Moderate stimulation and focus with mild anxiety/jitters, low euphoria

    Stimulation / Energy×3
    7
    Euphoria / Mood Lift×2
    2
    Focus / Productivity×2
    7
    Anxiety / Jitters×1
    5
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Pramiracetam

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Experience Report Analysis

    Erowid
    4 Reports
    2007–2014 Date Range
    3 With Age Data

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Real-World Dose Distribution

    62K Doses

    From 8 individual dose entries

    Oral (n=8)

    Median: 450.0mg 25th: 337.5mg 75th: 600.0mg 90th: 720.0mg
    mg/kg median: 5.735 mg/kg 75th: 6.962
    Read full reports on Erowid →

    References

    Data Sources

    Cited References

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