PRE-084
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- classified Tentative
- classified Research-chemical
- 4 corroborating sources
- 3 ROAs with full dose ladders
- duration data present
- classified Tentative
- classified Research-chemical
Aliases: Fenclimorate
Summary
PRE-084 is used primarily as a research ligand. Human anecdotal reports describe mild cognitive stimulation, enhanced focus, and subtle mood-lifting properties with little recreational value. Pharmacokinetic work in mice shows rapid CNS penetration and a plasma half-life of approximately 3 hours; human kinetics remain uncharacterised.
Dose Information
Dose basis. Human dosing is not established in clinical literature; values are aggregated from scattered user reports and should be treated as exploratory only. Begin at the low end and titrate cautiously. If using the hydrochloride salt, note ≈10–12% higher mass than freebase for the same molar dose (freebase MW ≈317.4; HCl salt ≈353.9). Anecdotal reports describe perceptible effects at 10–30 mg with relatively rapid onset; burning/bitterness possible. Data quality: low/anecdotal. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-10mg | 10-30mg | 30-60mg | 60mg+ |
| Sublingual | 2-10mg | 10-30mg | 30-60mg | 60mg+ |
| Insufflated | 2-8mg | 8-20mg | 20-40mg | 40mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-45 min | 1-2 hrs | 1-2 hrs | 6-10 hrs |
| Sublingual | 15-45 min | 1-2 hrs | 1-2 hrs | 6-10 hrs |
| Insufflated | 5-15 min | 1-2 hrs | 1-2 hrs | 6-10 hrs |
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track PRE-084 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
PRE-084 Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 1-2 · light 2-10 · common 10-30 · strong 30-60 · heavy 60+ Sublingual dose (mg): threshold 1-2 · light 2-10 · common 10-30 · strong 30-60 · heavy 60+ Insufflated dose (mg): threshold 1-2 · light 2-8 · common 8-20 · strong 20-40 · heavy 40+ Oral duration: onset 15-45m · peak 1-2h · offset 1-2h · total 6-10h · after-effects 1-2h Sublingual duration: onset 15-45m · peak 1-2h · offset 1-2h · total 6-10h · after-effects 1-2h Insufflated duration: onset 5-15m · peak 1-2h · offset 1-2h · total 6-10h · after-effects 1-2h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 20 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
No controlled human data on tolerance. Anecdotal users report little acute tachyphylaxis but possible subtle blunting with daily use over >1 week; spacing use by 1–2 weeks likely minimizes carryover. Data quality: anecdotal/low.
Effects
- Mild mental stimulation
- Slight physical wakefulness
- Increased energy
- Stimulation
- Physical euphoria
- Analgesia
- Creativity enhancement
- Insomnia
- Nausea
- Headache
- Enhanced concentration
- Subtle mood elevation
- Cognitive euphoria
- Compulsive redosing
- Motor control loss
- Depersonalization
- Derealization
- Potentiation of other psychoactives
- Time distortion
- Consciousness disconnection
- Increased music appreciation
- Perception of bodily lightness
- Tactile enhancement
- Disinhibition
- Light sensitivity
- Tactile suppression
- Spatial disorientation
- Double vision
- Spontaneous physical sensations
- Visual disconnection
Helpful Links
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