PRE-084
Aliases: Fenclimorate
Summary
PRE-084 is used primarily as a research ligand. Human anecdotal reports describe mild cognitive stimulation, enhanced focus, and subtle mood-lifting properties with little recreational value. Pharmacokinetic work in mice shows rapid CNS penetration and a plasma half-life of approximately 3 hours; human kinetics remain uncharacterised.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-45 min | 1-2 hrs | 1-2 hrs | 2.2-4.8 hrs |
| Sublingual | 15-45 min | 1-2 hrs | 1-2 hrs | 2.2-4.8 hrs |
| Insufflated | 5-15 min | 1-2 hrs | 1-2 hrs | 2.1-4.2 hrs |
Tolerance
Tolerance Decay
Full tolerance
7d
Half tolerance
14d
Baseline
~28d
No controlled human data on tolerance. Anecdotal users report little acute tachyphylaxis but possible subtle blunting with daily use over >1 week; spacing use by 1–2 weeks likely minimizes carryover. Data quality: anecdotal/low.
Effects
Positive
- Mild mental stimulation
- Slight physical wakefulness
- Increased energy
- Stimulation
- Physical euphoria
- Analgesia
- Creativity enhancement
Negative
- Insomnia
- Nausea
- Headache
Positive
- Enhanced concentration
- Subtle mood elevation
- Cognitive euphoria
Negative
- Compulsive redosing
- Motor control loss
- Depersonalization
- Derealization
- Potentiation of other psychoactives
- Time distortion
- Consciousness disconnection
Positive
- Increased music appreciation
- Perception of bodily lightness
- Tactile enhancement
Negative
- Disinhibition
- Light sensitivity
- Tactile suppression
- Spatial disorientation
- Double vision
- Spontaneous physical sensations
- Visual disconnection
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