Summary
PRE-084 is used primarily as a research ligand. Human anecdotal reports describe mild cognitive stimulation, enhanced focus, and subtle mood-lifting properties with little recreational value. Pharmacokinetic work in mice shows rapid CNS penetration and a plasma half-life of approximately 3 hours; human kinetics remain uncharacterised. Off-target activity appears minimal at low doses but increases with higher concentrations.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 15-45 min | 1-2 hrs | 1-2 hrs | 1-2 hrs | 360-0 min |
| Sublingual | 15-45 min | 1-2 hrs | 1-2 hrs | 1-2 hrs | 360-0 min |
| Insufflated | 5-15 min | 1-2 hrs | 1-2 hrs | 1-2 hrs | 360-0 min |
Effects
Positive
- Mild mental stimulation
- Slight physical wakefulness
- Increased energy
- Stimulation
- Physical euphoria
- Analgesia
- Creativity enhancement
Negative
- Insomnia
- Nausea
- Headache
Positive
- Enhanced concentration
- Subtle mood elevation
- Cognitive euphoria
Negative
- Compulsive redosing
- Motor control loss
- Depersonalization
- Derealization
- Potentiation of other psychoactives
- Time distortion
- Consciousness disconnection
Positive
- Increased music appreciation
- Perception of bodily lightness
- Tactile enhancement
Negative
- Disinhibition
- Light sensitivity
- Tactile suppression
- Spatial disorientation
- Double vision
- Spontaneous physical sensations
- Visual disconnection