PRL-8-53 is an old nootropic (first researched in the 1970's) which disappeared and was just re-discovered. I found that measuring out 10mg and mixing with 10cc of water in a syringe makes administration much easier (please note that I did NOT inject myself with this strange chemical, and would not recommend doing so)....
PRL-8-53
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- classified Tentative
- classified Research-chemical
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- classified Tentative
- classified Research-chemical
Aliases: prl853
Summary
A nootropic research chemical first synthesized in the 70s. One study shows a drastic improvement in mid-term memory among users, but otherwise it is severely lacking in information surrounding it. It has no recreational potential.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 3-5mg | 5-10mg | 10-20mg | 20mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Peak |
|---|---|
| Oral | 4-6 hrs |
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Increased heart rate
- Nausea
- Headache
- Headaches
- Insomnia
- Vasoconstriction
- Motor impairment
- Sedation
Positive
- Wakefulness
- Motivation enhancement
- Focus enhancement
- Memory enhancement
- Anxiety suppression
- Cognitive euphoria
- Focus Enhancement
- Memory Enhancement
Negative
- Anxiety
- Irritability
Positive
- Increased music appreciation
- Increased libido
- Increased Music Appreciation
- Color enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Appetite Suppression
- Dulled perception
- Spontaneous physical sensations
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 2 reports 2 neutral visit
Smoking PRL I recently bought PRL-8-53. Snorted it, took it orally, but only recently I've decided to smoke it. I have a pen, and I modified it to work as a pipe. I've put about 30mg of this compound in the pen, grabbed a lighter, and then I heated the pipe.
PRL-8-53's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for PRL-8-53? Let us know. Reports are reviewed by moderators — this is not posted publicly.