PRL-8-53 is an old nootropic (first researched in the 1970's) which disappeared and was just re-discovered. I found that measuring out 10mg and mixing with 10cc of water in a syringe makes administration much easier (please note that I did NOT inject myself with this strange chemical, and would not recommend doing so)....
PRL-8-53
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- classified Tentative
- classified Research-chemical
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- classified Tentative
- classified Research-chemical
Aliases: prl853
Summary
A nootropic research chemical first synthesized in the 70s. One study shows a drastic improvement in mid-term memory among users, but otherwise it is severely lacking in information surrounding it. It has no recreational potential.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 3-5mg | 5-10mg | 10-20mg | 20mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Peak |
|---|---|
| Oral | 4-6 hrs |
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track PRL-8-53 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "PRL-8-53 (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
PRL-8-53
Unit
mg
Description
PRL-8-53 Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 2-3 · light 3-5 · common 5-10 · strong 10-20 · heavy 20+ Oral duration: peak 4-6h · after-effects 1-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 7.5 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Increased heart rate
- Nausea
- Headache
- Headaches
- Insomnia
- Vasoconstriction
- Motor impairment
- Sedation
Positive
- Wakefulness
- Motivation enhancement
- Focus enhancement
- Memory enhancement
- Anxiety suppression
- Cognitive euphoria
Negative
- Anxiety
- Irritability
Positive
- Increased music appreciation
- Increased libido
- Color enhancement
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Dulled perception
- Spontaneous physical sensations
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 1 neutral 1 cautionary visit
Smoking PRL I recently bought PRL-8-53. Snorted it, took it orally, but only recently I've decided to smoke it. I have a pen, and I modified it to work as a pipe. I've put about 30mg of this compound in the pen, grabbed a lighter, and then I heated the pipe.
PRL-8-53's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for PRL-8-53? Let us know. Reports are reviewed by moderators — this is not posted publicly.