Home
    Disclaimer

    Progesterone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 2 ROAs with full dose ladders
    • duration data present
    • toxicity data (PsychonautWiki, PubChem)

    Depressant

    Summary PsychonautWiki

    Pregn-4-ene-3,20-dione, also known as Progesterone or P4 is a steroid sex hormone of the progestogen class. It occurs naturally and is the bodies major progestogen.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 100-200mg 200-400mg 400-600mg 600mg+
    Rectal 100-200mg 200-400mg 400-600mg 600mg+
    Light Common Strong Heavy

    Import into PsychonautWiki Journal

    The PsychonautWiki Journal app includes Progesterone, but its built-in data can be thinner than ours. Importing this file adds a separate "Progesterone (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

    ⬇ Download import file Import this file as custom substances and you get "Progesterone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

    Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset days to weeks depending on duration of use

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects

    Negative
    • Motor impairment
    • Mild fatigue
    • Headache
    Neutral
    • Sedation
    • Dry joints
    • Creaky ligaments
    • Reduced water retention
    • Increased vascularity
    • Hot flashes
    • Night sweats
    Positive
    • Reduced anxiety
    • Anxiety suppression
    • Dream potentiation
    • Enhanced dream recall
    Negative
    • Brain fog
    • Irritability
    • Elevated aggression/drive
    Neutral
    • Libido swings
    • Mood volatility
    • Mood changes
    Positive
    • Increased music appreciation
    • Color enhancement
    • Tactile enhancement
    Negative
    • Decreased libido
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition
    Neutral
    • Dulled perception
    • Softening of skin

    Pill Identifiers

    7 known pill identifiers on record — view imprints, colors, shapes, and images
    →
    Progesterone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 PsychonautWiki