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    Disclaimer
    ☠ Nitazene-class opioids are extremely potent, often exceeding fentanyl in strength. Even trace amounts can be fatal. Naloxone should always be on hand.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Pronitazene

    Aliases: Protonitazene, Propoxynitazene

    Depressant Research-chemical Opioid

    Summary TheDrug.Wiki

    Active in double-digit microgram doses; steep dose-response curve. Volumetric dosing essential due to extreme potency. Multiple naloxone doses may be required for reversal.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 10-20 min 20-40 min 20-60 min 2-4 hrs 1-2 hrs
    Insufflated 1-5 min 5-15 min 20-60 min 2-4 hrs 1-2 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 6.1
    Strong 6/10

    Strong euphoria and itching/nausea with mild sedation and pain relief

    Euphoria / Warmth ×3
    10
    physical euphoria cognitive euphoria euphoria warmth
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    5
    sedation muscle relaxation
    ⚠ Itching / Nausea ×1
    10
    itching nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Pronitazene
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 5d Half tolerance 7d Baseline ~21d

    Pattern inferred from user reports on rapid tolerance build with short-acting potent opioids; exact kinetics unknown. Treat as anecdotal and err on conservative spacing between uses.

    Cross-Tolerances

    other opioids
    70%
    fentanyl analogues
    70%
    nitazenes
    80%

    Effects TheDrug.Wiki

    Positive
    • Physical euphoria
    • Pain relief
    • Muscle relaxation
    Negative
    • Itching
    • Respiratory depression
    • Nausea
    Neutral
    • Sedation
    • Nodding
    • Pupil constriction
    • Itchiness
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Reduced anxiety
    • Wakefulness
    • Motivation enhancement
    • Euphoria
    Negative
    • Constipation
    • Motivation suppression
    • Compulsive redosing
    • Anxiety
    Positive
    • Warmth
    • Increased music appreciation
    • Increased libido
    Negative
    • Appetite suppression
    • Light sensitivity
    • Disinhibition
    • Dehydration
    Neutral
    • Warm flush
    • Dulled perception
    • Internal hallucination

    Combinations TripSit

    Pronitazene's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki