This substance is very nice. Get a hot warm fuzzy feeling that lasts about 2 hours before it slowly fades off over the next 2-3 hours. Confidence is boosted, mood is elevated. Pain is taken away.
Pronitazene
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Protonitazene, Propoxynitazene
Summary
Active in double-digit microgram doses; steep dose-response curve. Volumetric dosing essential due to extreme potency. Multiple naloxone doses may be required for reversal.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. This is a microgram-active opioid: a normal milligram scale cannot weigh a dose of it accurately, and a weighing error here is measured in lethal multiples rather than percentages. Volumetric dosing is the only defensible method, and batch-to-batch potency in the unregulated supply varies enormously. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Threshold |
|---|---|
| Oral | 50ug |
| Insufflated | 10ug |
| Vaporized | 5ug |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 10-20 min | 20-40 min | 20-60 min | 2-4 hrs | 2.83-6 hrs |
| Insufflated | 1-5 min | 5-15 min | 20-60 min | 2-4 hrs | 2.43-5.33 hrs |
| Vaporized | 1-5 min | 5-10 min | 20-60 min | 2-4 hrs | 2.43-5.25 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.1
Strong
6/10
Strong euphoria and itching/nausea with mild sedation and pain relief
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
warmth
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
10
itching
nausea
constipation
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Pronitazene there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Name
Pronitazene
Unit
µg
Description
Pronitazene Source: SubstanceSearch (substancesearch.com) Oral dose (µg): threshold 50ug Insufflated dose (µg): threshold 10ug Vaporized dose (µg): threshold 5ug Oral duration: onset 10-20m · come-up 20-40m · peak 0.33-1h · offset 2-4h · total 2.83-6h · after-effects 1-2h Insufflated duration: onset 1-5m · come-up 5-15m · peak 0.33-1h · offset 2-4h · total 2.43-5.33h · after-effects 1-2h Vaporized duration: onset 1-5m · come-up 5-10m · peak 0.33-1h · offset 2-4h · total 2.43-5.25h · after-effects 1-2h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
5d
Half tolerance
7d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Pattern inferred from user reports on rapid tolerance build with short-acting potent opioids; exact kinetics unknown. Treat as anecdotal and err on conservative spacing between uses.
Cross-Tolerances
Effects
Positive
- Physical euphoria
- Pain relief
- Muscle relaxation
Negative
- Itching
- Respiratory depression
- Nausea
- Sedation
- Nodding
- Pupil constriction
- Itchiness
Positive
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Euphoria
Negative
- Constipation
- Motivation suppression
- Compulsive redosing
- Anxiety
Positive
- Warmth
- Increased music appreciation
- Increased libido
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Warm flush
- Dulled perception
- Internal hallucination
Combinations
Cross-Check Pronitazene with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
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Helpful Links
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