Summary
Active in double-digit microgram doses; steep dose-response curve. Volumetric dosing essential due to extreme potency. Multiple naloxone doses may be required for reversal. Powder has appeared mis-sold as ketamine and heroin; lab confirmation strongly advised. Approximately 3 times more potent than fentanyl and 200 times more potent than morphine.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 10-20 min | 20-40 min | 20-60 min | 2-4 hrs | 1-2 hrs |
| Insufflated | 1-5 min | 5-15 min | 20-60 min | 2-4 hrs | 1-2 hrs |
| Vaporized | 1-5 min | 5-10 min | 20-60 min | 2-4 hrs | 1-2 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Physical euphoria
- Pain relief
- Muscle relaxation
Negative
- Itching
- Respiratory depression
- Nausea
- Sedation
- Nodding
- Pupil constriction
- Itchiness
Positive
- Cognitive euphoria
- Anxiety suppression
- Reduced anxiety
- Wakefulness
- Motivation enhancement
- Euphoria
Negative
- Constipation
- Motivation suppression
- Compulsive redosing
- Anxiety
Positive
- Warmth
- Increased music appreciation
- Increased libido
Negative
- Appetite suppression
- Light sensitivity
- Disinhibition
- Dehydration
- Warm flush
- Dulled perception
- Internal hallucination