This substance is very nice. Get a hot warm fuzzy feeling that lasts about 2 hours before it slowly fades off over the next 2-3 hours. Confidence is boosted, mood is elevated. Pain is taken away.
Pronitazene
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- 29 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Protonitazene, Propoxynitazene
Summary
Active in double-digit microgram doses; steep dose-response curve. Volumetric dosing essential due to extreme potency. Multiple naloxone doses may be required for reversal.
Dose Information
Dose basis. The dose figures on this page are not clinical data. They are aggregated from community reports by a secondary source whose own notes state there is no human pharmacokinetic study behind them, and our internal audit flags this substance's dosing as unverifiable. Treat them as a rough orientation, not a safe range. This is a microgram-active opioid: a normal milligram scale cannot weigh a dose of it accurately, and a weighing error here is measured in lethal multiples rather than percentages. Volumetric dosing is the only defensible method, and batch-to-batch potency in the unregulated supply varies enormously. Assume full respiratory depression, keep naloxone to hand, never dose alone, and never combine with benzodiazepines, alcohol or other depressants.
| ROA | Threshold |
|---|---|
| Oral | 50ug |
| Insufflated | 10ug |
| Vaporized | 5ug |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Sources
Oral
Dose ladder — DrugsPROInsufflated
Dose ladder — DrugsPROVaporized
Dose ladder — DrugsPROOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 10-20 min | 20-40 min | 20-60 min | 2-4 hrs | 2.83-6 hrs |
| Insufflated | 1-5 min | 5-15 min | 20-60 min | 2-4 hrs | 2.43-5.33 hrs |
| Vaporized | 1-5 min | 5-10 min | 20-60 min | 2-4 hrs | 2.43-5.25 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.1
Strong
6/10
Strong euphoria with strong itching/nausea, mild sedation and pain relief
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
warmth
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
10
itching
nausea
constipation
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Cross-Tolerances
other opioids
fentanyl analogues
nitazenes
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check Pronitazene with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
Pronitazene's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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Name
Pronitazene
Unit
µg
Description
Pronitazene Source: SubstanceSearch (substancesearch.com) Oral dose (µg): threshold 50ug Insufflated dose (µg): threshold 10ug Vaporized dose (µg): threshold 5ug Oral duration: onset 10-20m · come-up 20-40m · peak 0.33-1h · offset 2-4h · total 2.83-6h · after-effects 1-2h Insufflated duration: onset 1-5m · come-up 5-15m · peak 0.33-1h · offset 2-4h · total 2.43-5.33h · after-effects 1-2h Vaporized duration: onset 1-5m · come-up 5-10m · peak 0.33-1h · offset 2-4h · total 2.43-5.25h · after-effects 1-2h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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