There a few interesting and somewhat surprising effects that result from Propofol. My experience with Propofol was a clinical one; it was the drug used to induce a general anesthesia. Essentially, it was used to take me under, and then a different substance was used to keep me there for the duration of the anesthesia.
Propofol
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Aliases: Diprivan, Milk-of-amnesia
Summary
A very short acting sedative that is usually given at the start of general anesthesia, and for maintenance of the prior. It should never be used outside of a medical setting. With that in mind, if you do plan to use this drug recreational, please have a very experienced friend with you that has the skills to insert a cannula, and monitor you very closely.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Intravenous | 10-30mg | 30-60mg | 60-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak |
|---|---|---|
| Intravenous | 0-2 min | 10-20 min |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Tolerance Decay
Full tolerance
3d
Half tolerance
8d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 16 Erowid experience reports
Positive Effects 4
Sedation
50.0%
70%
Euphoria
37.5%
70%
Stimulation
25.0%
70%
Anxiety Suppression
18.8%
70%
Adverse Effects 2
Confusion
25.0%
70%
Memory Suppression
25.0%
70%
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 6 neutral 2 cautionary visit
Never really been too shy about trying new drugs--just for the sake of the experience. I do tend to research a chemical pretty well before messing-around with it, this includes Propofol.
My experience with Propofol isnt a very long one, mostly because I cant really remember any of it at all. I will, however, tell what I do remember from the experience. I was over at my friends house, lets call him B.
So ive had the sad experience of this only when going under.. However, its largely circulated. This gets passed thoroughly in the Med. Office among co workers and peers in the field.. its said to be highly abusive for professionals,.. In either case, mostly attainable if one know someone who knows someone blah blah.
Propofol I had an endoscopy first thing in the morning the day Barac Obama was elected. I have had nausea and vomiting for like 3 years now. And the doctor wanted to check out the inside of my stomach for himself. The proporfol was given through a drip.
I went to the Endoscopy center to get a flex and a EGD done, I was very nervous as I have a fear of needles and getting an IV didn't help that any, nor did the fear of the rectal scope. But they brought me into the room and talked to me for a while explaining the procedure and the diprivan (propofol IV).
I was to have an operation using Propofol but curious about it so I googled for info. I was in the local hospital for gallbladder removal. The surgeon had explained the procedure well to me and talked about the anaesthesia agent.
I was administered IV Propofol for a colonoscopy this A.M. I can only recall waking up, with immediate realization of effects. I immediately asked the nurse, 'what is the drug that they administered'? She said 'it is the drug that Michael Jackson overdosed on'; which I thought was humorous, as if I'd run out, and buy i...
Bluelight 1 thread 1 neutral visit
EDIT: Dosage was 200mg according to the letter I received. I think it might be the standard dose on there, they turned up the infusion when I started to resist their pushing the endoscope into my throat. That's when I passed out for a bit according to what I was told.
Propofol's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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