Proscaline - Substance Search

Summary TheDrug.Wiki TripSit PsychonautWiki

Proscaline is a lesser-known mescaline analog approximately five to seven times more potent than mescaline. The substance has minimal research into its pharmacology, toxicity, and long-term effects. Use a precise milligram scale for accurate dosing.

Perspectives

“Proscaline dulled my sense of pain and made the other senses really sharp. Everything felt really soft, and clean and clear. I could feel every hair my hand was touching. I felt so relaxed and at ease. I know that under the appropriate circumstances, this material would lead to uninhibited eroticism.”

— Alexander Shulgin, PiHKAL (with 30 mg)

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	15-30mg	30-40mg	40-60mg	60mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	30-60 min	1-2 hrs	2-4 hrs	3-5 hrs	3-5 hrs	6.5-12 hrs

Effect Profile

8 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 6.5

Strong 6/10

Strong visuals with moderate headspace and body load

Visual Intensity ×3

10

colour enhancement drifting tracers pattern recognition enhancement colour shifting after images +2 more

Headspace Depth ×3

6

conceptual thinking emotion enhancement time distortion confusion

Auditory Effects ×1

0

⚠ Body Load / Somatic Effects ×1

6

nausea bodily pressures muscle tension

Stimulant 4.6

Moderate+ 5/10

Moderate euphoria with mild stimulation and anxiety/jitters, low focus

Stimulation / Energy ×3

5

stimulation wakefulness

Euphoria / Mood Lift ×2

6

physical euphoria euphoria

Focus / Productivity ×2

2

analysis enhancement

⚠ Anxiety / Jitters ×1

4

restlessness muscle tension

Based on reports from:

PiHKAL PiHKAL #140: P Erowid Experience Reports PsychonautWiki Proscaline

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 1d Half tolerance 21d Baseline ~35d

Effects Erowid

Aggregated from 8 Erowid experience reports

Positive Effects 6

Color Enhancement 50.0% 70%

Focus Enhancement 50.0% 70%

Euphoria 50.0% 70%

Music Enhancement 37.5% 70%

Body High 37.5% 70%

Tactile Enhancement 37.5% 70%

Adverse Effects 5

Nausea 50.0% 70%

Sweating 37.5% 70%

Muscle Tension 37.5% 70%

Anxiety 37.5% 70%

Confusion 37.5% 70%

Combinations TripSit

PiHKAL / TiHKAL Shulgin

PiHKAL #140: P

“Proscaline dulled my sense of pain and made the other senses really sharp. Everything felt really soft, and clean and clear. I could feel every hair my hand was touching. I felt so relaxed and at ease. I know that under the appropriate circumstances, this material would lead to uninhibited eroticism.”

— Alexander Shulgin, PiHKAL (with 30 mg)

Proscaline's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

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