A Wonderfully Complete Musical Experience First proscaline trial, dosage 30mg + 15mg 45 minutes in, all orally Expectations: an idea of the effects of this drug, and hopefully some musical enhancement as I had recently read about 2:15pm - Ingested 30mg, orally, of proscaline, received as a flaky, shiny batch of crystal...
Proscaline
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Aliases: P, 4-propoxy-3,5-dmpea
Summary
Proscaline (4-propoxy-3,5-DMPEA) is a lesser-known psychedelic phenethylamine and mescaline analog. There has been minimal research into its pharmacology, toxicity, and long-term effects. It is approximately five to seven times more potent than mescaline, so a precise milligram scale should be used for accurate dosing.
Perspectives
“Proscaline dulled my sense of pain and made the other senses really sharp. Everything felt really soft, and clean and clear. I could feel every hair my hand was touching. I felt so relaxed and at ease. I know that under the appropriate circumstances, this material would lead to uninhibited eroticism.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 15-30mg | 30-40mg | 40-60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-2 hrs | 2-4 hrs | 3-5 hrs | 6-12 hrs |
Effect Profile
8 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
6.5
Strong
6/10
Strong visuals with moderate headspace and body load
Visual Intensity
×3
10
colour enhancement
drifting
tracers
pattern recognition enhancement
colour shifting
after images
+2 more
Headspace Depth
×3
6
conceptual thinking
emotion enhancement
time distortion
confusion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
6
nausea
bodily pressures
muscle tension
Stimulant
4.6
Moderate+
5/10
Moderate euphoria with mild stimulation and anxiety/jitters, low focus
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
6
physical euphoria
euphoria
Focus / Productivity
×2
2
analysis enhancement
Anxiety / Jitters
×1
4
restlessness
muscle tension
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7โ14 days for partial reset; full reset may take weeks โ tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 8 Erowid experience reports
Positive Effects 6
Color Enhancement
50.0%
70%
Focus Enhancement
50.0%
70%
Euphoria
50.0%
70%
Music Enhancement
37.5%
70%
Body High
37.5%
70%
Tactile Enhancement
37.5%
70%
Adverse Effects 5
Nausea
50.0%
70%
Sweating
37.5%
70%
Muscle Tension
37.5%
70%
Anxiety
37.5%
70%
Confusion
37.5%
70%
Combinations
Cross-Check Proscaline with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 7 reports 7 neutral visit
Proscaline Trip Report: 50mg, capsule, orally I have had a bit of experience with mescaline analogs in my day, starting with 2C-E, 2C-T-2, and 2C-I, as well as Allylescaline, and 2C-B later on. To this particular experience, I felt what's been listed is the most relevant.
Setting: Friday afternoon on a mild Spring day. The plan is to go for a long walk through a nature area in a nearby park, which Iยve been looking forward to since the warmer weather arrived. Mindset: First dose taken towards the end of my workday, about ninety minutes before logging off (from working from home).
[This report originally appeared in the Shulgin Lab Book 5 , Book 5 PDF page 108, 109.] Since you noticed my behavior and observed before you and Ann went to bed I'll mostly deal with after experiences. It purveyed a warm tingly sensation with any contact and I found myself very open to discussion.
20160809 (Tuesday 9th of August). Subject: Male, 30 years of age, ~85 Kg. (~187,5 Lbs). Substance: ~102mg Proscaline that has been sitting in the dark in its baggy. Mostly at room temperature with peaks to ~35ยฐ (max ~40ยฐ) Celsius in the summer. Setting: At home, mostly in my living room, alone. Feeling fine/good.
Proscaline Party I recently acquired a gram of Proscaline and after my last experiments with it, I decided that the time had come to throw a Proscaline party. At 6:40, I filled four capsules with 112mg, and downed one while licking any remnants off of the scoop I used.
[This report originally appeared as handwritten notes in the Shulgin Lab Book 2 , PDF page 14] + 15mg 1/7/77 9:05AM ATS - no noticeable onset of anything. The middle of the day was relaxed, and beset with many trivial acts of bad judgment [e.g., turning of the car engine to get out to open the gate, opening wrong drawe...
Bluelight 5 threads 5 neutral visit
4-24-17 - First proscaline trial, dosage 30mg + 15mg 45 minutes in, all orally Expectations: an idea of the effects of this drug, and hopefully some musical enhancement as I had recently read about โ 2:15pm - Ingested 30mg, orally, of proscaline, received as a flaky, shiny batch of crystal shards.
PROSCALINE 39mg orally - First Time - "Tripping into the Ordinary, An Extra Ordinary Experience" Background: I have experience with a few dozen classical and RC psychedelics, as well as some dissociatives, stimulants, depressants, empathogens, and weird botanicals.
Decided to try some proscaline once it became available... had read about it a bit, but unfortunately there wasnt a lot of info on it. im not the bravest person in the world, but the substance seemed pretty benign and dosage wise pretty forgiving so i decided to try it on a weekend outing.
20160809 (Tuesday 9th of August). Subject: Male, 30 years of age, ~85 Kg. (~187,5 Lb's). Substance: ~102mg Proscaline that has been sitting in the dark in it's baggy. Mostly at room temperature with peaks to ~35ยฐ (max ~40ยฐ) Celsius in the summer. Setting: At home, mostly in my living room, alone. Feeling fine/good.
been doing a lot of drugs recently mostly psychs, i would consider myself experienced with psychs, s here's a short report of my proscaline trial, since there isn't much info out there on it. I dropped 70mg alone (measured on a mg scale), the experience was gentle, nearly no OEV's.
PiHKAL / TiHKAL
PiHKAL #140: P
“Proscaline dulled my sense of pain and made the other senses really sharp. Everything felt really soft, and clean and clear. I could feel every hair my hand was touching. I felt so relaxed and at ease. I know that under the appropriate circumstances, this material would lead to uninhibited eroticism.”
Proscaline's nerd page
Pharmacology, chemical data, effect profiles, and more
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