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    Pyrovalerone molecular structure

    Pyrovalerone Stats & Data

    O-2371 Centroton Thymergix 4-methyl-β-keto-prolintane
    NPS DataHub
    MW245.36
    FormulaC16H23NO
    CAS3563-49-3
    IUPAC1-(4-methylphenyl)-2-pyrrolidin-1-ylpentan-1-one
    SMILESCCCC(N1CCCC1)C(=O)c1ccc(C)cc1
    InChIKeySWUVZKWCOBGPTH-UHFFFAOYSA-N
    Phenethylamines; Cathinones; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Chemical Class Amphetamine
    Psychoactive Class Stimulant
    Half-Life No modern human PK. Animal and class data suggest a short half-life (few hours) and prolonged subjective after‑effects; use conservative spacing between trials.

    Effect Profile

    Curated
    Stimulant 4.1

    Strong anxiety/jitters with moderate euphoria, mild stimulation, low focus

    Stimulation / Energy×3
    5
    Euphoria / Mood Lift×2
    6
    Focus / Productivity×2
    3
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    No modern human PK. Animal and class data suggest a short half-life (few hours) and prolonged subjective after‑effects; use conservative spacing between trials.
    Addiction Potential
    High: pyrrolidinophenone stimulants strongly inhibit DAT/NET, have short-acting, high-reinforcement profiles, and are linked to compulsive redosing and binges; risk comparable to α‑PVP/MDPV class.

    Tolerance Decay

    Full tolerance 1d Half tolerance 3d Baseline ~10d

    Model is an anecdotal approximation based on pyrrolidinophenone user reports: rapid escalation during binges with partial recovery over several days; cross‑tolerance within the class is expected given shared DAT/NET inhibition. Treat this as a planning aid for spacing sessions, not a guarantee. Data quality: anecdotal/community‑derived.

    Cross-Tolerances

    MDPV
    70% ●●○
    α‑PVP
    80% ●●○
    Other pyrrolidinophenones
    60% ●○○

    Harm Reduction

    drugs.wiki

    Reasoning and harm-reduction justifications (with citations): 1) Chemical identity and synonyms are confirmed on PubChem; pyrovalerone is the parent of the α‑pyrrolidinophenone class (α‑PVP is desmethyl‑pyrovalerone), supporting cross‑tolerance/similar risks. 2) Dose and duration data for pyrovalerone are sparse; α‑PVP vaults and extensive community reports show fast onset, short peak, and prolonged residual stimulation with strong redose drive, so conservative, estimate‑level timings were used and clearly labeled. 3) The pyrrolidinophenone class has documented health harms and dependence/compulsion potential in EU risk assessments (α‑PVP/MDPV), supporting a high addiction potential warning for pyrovalerone as a close analog. 4) Combining stimulants with MAOIs or other stimulants is widely flagged as dangerous by harm‑reduction orgs (TripSit combo guidance) and stimulant basics (DrugWise); this underpins the interactions table. 5) Because potency is high and scales are often imprecise at low mg, volumetric dosing is recommended; TripSit provides a community volumetric converter tool. 6) Reagent color tests have limitations for distinguishing similar cathinones; lab‑grade drug checking (GC‑MS/FT‑IR/LC‑MS) via community services (e.g., DrugsData/Erowid network) is recommended where available. 7) IV use significantly increases infection and overdose/arrhythmia risks; if people inject, sterile technique and syringe exchange practices reduce BBV transmission and other harms (general HR guidance). 8) Class‑level in vitro toxicity concerns have been reported for pyrovalerones (discussion summarizing peer‑reviewed data is cited within Bluelight HR discussions), justifying conservative dosing and spacing. 9) Given rarity and mislabeling risks in unregulated markets, pre‑portioning a session cap, avoiding rapid redosing, hydration with electrolytes, cooling strategies, and sleep planning mirror HR for α‑PVP/MDPV and general stimulant guidance.

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