Quetiapine
Aliases: Derin, Seroquel, Xeroquel, Ketilept, Ketipinor
Summary
Quetiapine is primarily prescribed for schizophrenia, bipolar disorder, and as adjunct therapy in major depressive disorder. Off-label use for insomnia is common but not recommended due to metabolic side effects, weight gain, and risk of orthostatic hypotension. Recreational misuse is driven by sedative and anxiolytic properties rather than euphoric effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-50mg | 50-150mg | 150-300mg | 300mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-40 min | 30-60 min | 1.5-6 hrs | 6-7 hrs | 8.3-14.7 hrs |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Aggregated from 127 Erowid experience reports
Positive Effects 12
Stimulation
43.3%
70%
Anxiety Suppression
41.7%
70%
Sedation
40.9%
70%
Euphoria
17.3%
70%
Empathy
14.2%
70%
Color Enhancement
13.4%
70%
Focus Enhancement
11.0%
70%
Tactile Enhancement
9.4%
70%
Music Enhancement
9.4%
70%
Introspection
5.5%
70%
Creativity Enhancement
3.1%
70%
Body High
3.1%
70%
Adverse Effects 11
Confusion
21.3%
70%
Psychosis
18.9%
70%
Memory Suppression
10.2%
70%
Motor Impairment
7.9%
70%
Nausea
7.1%
70%
Seizure
5.5%
70%
Headache
3.9%
70%
Muscle Tension
3.9%
70%
Pupil Dilation
3.9%
70%
Sweating
3.1%
70%
Increased Heart Rate
2.4%
70%
Pill Identifiers
40
known pill identifiers on record — view imprints, colors, shapes, and images
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Quetiapine's nerd page
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