This drug is not fun. If you are incredibly desperate to fall asleep, it could be helpful. But I took 50mg around 1am and tried to stay awake, but was asleep by 1:30. I was texting some friends but had to stop due to an overwhelming urge to sleep. My legs felt restless and I was extremely uncomfortable.
Quetiapine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- PubChem toxicity data
Aliases: Derin, Seroquel, Xeroquel, Ketilept, Ketipinor
Summary
Quetiapine is primarily prescribed for schizophrenia, bipolar disorder, and as adjunct therapy in major depressive disorder. Off-label use for insomnia is common but not recommended due to metabolic side effects, weight gain, and risk of orthostatic hypotension. Recreational misuse is driven by sedative and anxiolytic properties rather than euphoric effects.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-50mg | 50-150mg | 150-300mg | 300mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-40 min | 30-60 min | 1.5-6 hrs | 6-7 hrs | 4-8 hrs |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Tolerance Decay
Half tolerance
6d
Baseline
~14d
Effects
Aggregated from 127 Erowid experience reports
Positive Effects 12
Stimulation
43.3%
70%
Anxiety Suppression
41.7%
70%
Sedation
40.9%
70%
Euphoria
17.3%
70%
Empathy
14.2%
70%
Color Enhancement
13.4%
70%
Focus Enhancement
11.0%
70%
Tactile Enhancement
9.4%
70%
Music Enhancement
9.4%
70%
Introspection
5.5%
70%
Creativity Enhancement
3.1%
70%
Body High
3.1%
70%
Adverse Effects 11
Confusion
21.3%
70%
Psychosis
18.9%
70%
Memory Suppression
10.2%
70%
Motor Impairment
7.9%
70%
Nausea
7.1%
70%
Seizure
5.5%
70%
Headache
3.9%
70%
Muscle Tension
3.9%
70%
Pupil Dilation
3.9%
70%
Sweating
3.1%
70%
Increased Heart Rate
2.4%
70%
Community Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 8 reports 1 positive 4 neutral 3 cautionary visit
Ok, so this is actually two separate stories. Each took place within a week of the other (2006), but the first account was written a few days after, and the second was written about a year later (2007). And it is now being reposted 2 years later (2008).
Well I'm all over the place right now. I'm currently on my daily dose of 200 mg of seroquel for an as of yet undiagnosed psychiatric condition, probably bipolar based on my manic symptoms. I started seroquel treatment 10 days ago.
I've been taking Quetiapine (Seroquel) for insomnia for the last couple months. I am one of the unfortunate group of people who are recovering from substance abuse and addiction, but also have a sleep disorder.
This report is more for people who are being prescribed or thinking about accepting their all-knowing shrink's offer to perscribe them Seroquel, not recreational users... If I ever caught someone using seroquel recreationally I would have to smack them upside the head and laugh in their face as a matter of principle.
[Erowid Note: The doses described in this report are potentially life threatening. The amount taken is beyond a heavy dose and could pose serious health risks or result in unwanted, extreme effects. Doses such as this have been known to cause hospitalizations and/or deaths.
I have been incorrectly diagnosed with different mental illnesses throughout my life, ranging from ADD to Bipolar Disorder. After a great deal of research of the symptoms of various mental conditions I have concluded that there is nothing 'wrong' with me.
I have had anxiety as long as I can remember. I have been diagnosed recently by my psychiatrist as having general anxiety disorder, depression, post traumatic stress disorder, and border line personality disorder. I had a very traumatic childhood, and anxiety runs very strong in my family.
Bluelight 3 threads 3 neutral visit
I hope this qualifies as a trip report. I'll just go ahead and tell you what went down last night... So it's friday night and I'm watching the baby while my girlfriend is off to work.
So, I'm a freshman where I'm from and very inexperienced when it comes to drugs. Mainly I just smoke pot and drink but I decided one day to try Seroquel because it's all I had, and my dumbass friend "assured" me it would get me high. So anyway, I pop 4 seroquel tablets (100 MG'S) so I've now taken 400 MG of Seroquel.
Took 30 pills of seroquel each 300 mg. I Dont remember much of the time afterwards but I was in my bathroom and then walked downstairs and passed out. My roomates took me to the ER, I was having siezures at this time.
Pill Identifiers
40
known pill identifiers on record — view imprints, colors, shapes, and images
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Quetiapine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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