Summary
Quetiapine is primarily prescribed for schizophrenia, bipolar disorder, and as adjunct therapy in major depressive disorder. Off-label use for insomnia is common but not recommended due to metabolic side effects, weight gain, and risk of orthostatic hypotension. Recreational misuse is driven by sedative and anxiolytic properties rather than euphoric effects. Risk of tardive dyskinesia is lower than typical antipsychotics but still present with long-term use. Monitor blood glucose and lipid levels during treatment.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 25-50mg | 50-150mg | 150-300mg | 300mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 20-40 min | 30-60 min | 1.5-6 hrs | 6-7 hrs | 24-48 hrs | 240-0 min |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Positive
- Physical Euphoria
- Stimulation
- Muscle Relaxation
- Bronchodilation
Negative
- Dry mouth
- Fatigue
- Headache
- Increased blood pressure
- Headaches
- Sedation
Positive
- Anxiety suppression
- Dream potentiation
Negative
- Drowsiness
- Emotion suppression
- Thought deceleration
- Cognitive dulling
- Motor control loss
- Dizziness
- Constipation
- Amnesia
- Analysis suppression
- Information processing suppression
- Language suppression
Positive
Negative
- Dehydration
- Light sensitivity
- Disinhibition
- Appetite Suppression
- Decreased Libido
- Orgasm Suppression
- Appetite intensification
- Appetite change
- Dulled perception
- Internal Hallucination