Summary
Rasagiline irreversibly acylates the flavin site of MAO-B, giving approximately 90% inhibition at 1 mg/day within 1-2 weeks. Although its plasma half-life is approximately 3 h, functional recovery depends on MAO-B resynthesis (approximately 40 days), so a single 1 mg dose can keep tyramine thresholds lower for several days. Selectivity diminishes above 2 mg/day, raising dietary and pressor risk comparable to classical non-selective MAOIs. Case surveys and pharmacovigilance reviews document serotonin-syndrome clusters when rasagiline is combined with SSRIs or MDMA-like agents—even at therapeutic doses. Bluelight users typically employ 0.5-1 mg to amplify phenethylamine or stimulant effects, reporting brighter mood, clearer focus, and longer stimulant plateau, but also warn that >2 mg 'feels wired' and makes tyramine flushes more likely.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects |
|---|---|---|---|---|
| Oral (Tablet; Sublingually Dissolved) | 30-60 min | 1-2 hrs | 12-24 hrs | 12 hrs |
| Oral (Powder / Capsule) | 30-60 min | 1-2 hrs | 12-24 hrs | 12 hrs |
Tolerance
Effects
- Reduced fatigue
- Stimulation
- Slight appetite suppression
- Occasional insomnia
- Increased heart rate
- Subtle mental alertness
- Enhanced motivation
- Mild euphoria
- Vivid dreams
- Alertness enhancement
- Talkativeness
- Light sensitivity