Summary
Rasagiline irreversibly acylates the flavin site of MAO-B, giving approximately 90% inhibition at 1 mg/day within 1-2 weeks. Although its plasma half-life is approximately 3 h, functional recovery depends on MAO-B resynthesis (approximately 40 days), so a single 1 mg dose can keep tyramine thresholds lower for several days. Selectivity diminishes above 2 mg/day, raising dietary and pressor risk comparable to classical non-selective MAOIs.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset |
|---|---|---|---|
| Oral (Tablet; Sublingually Dissolved) | 30-60 min | 1-2 hrs | 12-24 hrs |
| Oral (Powder / Capsule) | 30-60 min | 1-2 hrs | 12-24 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
2.5
Light
2/10
Mild stimulation with low anxiety/jitters
Stimulation / Energy
×3
4
stimulation
alertness enhancement
Euphoria / Mood Lift
×2
0
Focus / Productivity
×2
0
Anxiety / Jitters
×1
2
increased heart rate
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d
Effects
Positive
- Reduced fatigue
- Stimulation
Negative
- Slight appetite suppression
- Occasional insomnia
- Increased heart rate
Positive
- Subtle mental alertness
- Enhanced motivation
- Mild euphoria
- Vivid dreams
- Alertness enhancement
- Talkativeness
Negative
- Light sensitivity
Pill Identifiers
12
known pill identifiers on record — view imprints, colors, shapes, and images
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Rasagiline's nerd page
Pharmacology, chemical data, effect profiles, and more
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