Rasagiline
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 2 corroborating sources
- duration data present
- 27 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- duration data present
- 27 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Aliases: Azilect, Tvp-1012, Agn-1135
Summary
Rasagiline irreversibly acylates the flavin site of MAO-B, giving approximately 90% inhibition at 1 mg/day within 1-2 weeks. Although its plasma half-life is approximately 3 h, functional recovery depends on MAO-B resynthesis (approximately 40 days), so a single 1 mg dose can keep tyramine thresholds lower for several days. Selectivity diminishes above 2 mg/day, raising dietary and pressor risk comparable to classical non-selective MAOIs. Like other monoamine oxidase inhibitors (MAOIs), it must not be combined with meperidine (pethidine), tramadol, methadone or dextromethorphan.
Dose Information
| ROA | Threshold |
|---|---|
| Oral (Tablet; Sublingually Dissolved) | 0.25mg |
| Oral (Powder / Capsule) | 0.25mg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Sources
Oral (Tablet; Sublingually Dissolved)
Dose ladder — DrugsPROOral (Powder / Capsule)
Dose ladder — DrugsPROOnset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral (Tablet; Sublingually Dissolved) | 30-60 min | 1-2 hrs | 12-24 hrs | 13.5-27 hrs |
| Oral (Powder / Capsule) | 30-60 min | 1-2 hrs | 12-24 hrs | 13.5-27 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild stimulation with low anxiety/jitters
Tolerance
Tolerance Decay
Effects
Effect glossary — · full glossary
Combinations
Cross-Check Rasagiline with another substanceRasagiline blocks MAO-B, and its selectivity fades above 2 mg a day, so these are TripSit's MAOI interactions as a cautious stand-in: the dangers apply, but any boost to DMT or mushrooms is likely weaker than with the MAO-A inhibitors in ayahuasca. Its US label rules out meperidine (pethidine), tramadol, methadone, dextromethorphan and St John's wort, and warns against antidepressants.
Pill Identifiers
Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Rasagiline there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Rasagiline Source: SubstanceSearch (substancesearch.com) Oral (Tablet; Sublingually Dissolved) dose (mg): threshold 0.25 Oral (Powder / Capsule) dose (mg): threshold 0.25 Oral (Tablet; Sublingually Dissolved) duration: onset 0.5-1h · peak 1-2h · offset 12-24h · total 13.5-27h · after-effects 12h Oral (Powder / Capsule) duration: onset 0.5-1h · peak 1-2h · offset 12-24h · total 13.5-27h · after-effects 12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
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