Rasagiline
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- dose data not in PW/TripSit (unverifiable)
- 1 source
- duration data present
- dose data not in PW/TripSit (unverifiable)
Aliases: Azilect, Tvp-1012, Agn-1135
Summary
Rasagiline irreversibly acylates the flavin site of MAO-B, giving approximately 90% inhibition at 1 mg/day within 1-2 weeks. Although its plasma half-life is approximately 3 h, functional recovery depends on MAO-B resynthesis (approximately 40 days), so a single 1 mg dose can keep tyramine thresholds lower for several days. Selectivity diminishes above 2 mg/day, raising dietary and pressor risk comparable to classical non-selective MAOIs.
Dose Information
| ROA | Threshold |
|---|---|
| Oral (Tablet; Sublingually Dissolved) | 0.25mg |
| Oral (Powder / Capsule) | 0.25mg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral (Tablet; Sublingually Dissolved) | 30-60 min | 1-2 hrs | 12-24 hrs | 13.5-27 hrs |
| Oral (Powder / Capsule) | 30-60 min | 1-2 hrs | 12-24 hrs | 13.5-27 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Mild stimulation with low anxiety/jitters
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Rasagiline there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Rasagiline Source: SubstanceSearch (substancesearch.com) Oral (Tablet; Sublingually Dissolved) dose (mg): threshold 0.25 Oral (Powder / Capsule) dose (mg): threshold 0.25 Oral (Tablet; Sublingually Dissolved) duration: onset 0.5-1h · peak 1-2h · offset 12-24h · total 13.5-27h · after-effects 12h Oral (Powder / Capsule) duration: onset 0.5-1h · peak 1-2h · offset 12-24h · total 13.5-27h · after-effects 12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Reduced fatigue
- Stimulation
- Slight appetite suppression
- Occasional insomnia
- Increased heart rate
- Subtle mental alertness
- Enhanced motivation
- Mild euphoria
- Vivid dreams
- Alertness enhancement
- Talkativeness
- Light sensitivity
Pill Identifiers
Helpful Links
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