Rolicyclidine Stats & Data
C1CCC(CC1)(N1CCCC1)c1ccccc1FYOWWXMGDATDQY-UHFFFAOYSA-NPharmacology
DrugBankDescription
Rolicyclidine (PCPy) is classified as a dissociative anesthetic agent. It also has hallucinogenic and sedative properties. Because of its pharmacodynamic similarity to the drug phencyclidine (PCP), rolicyclidine was added to the Schedule I list of illegal drugs in the USA in the 1970s.
Mechanism of Action
Rolicyclidine works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA Receptor.
Pharmacodynamics
Rolicyclidine is similar in effects to phencyclidine but is slightly less potent and has less stimulant effects. Instead it acts by inducing a sedative effect described as being somewhat similar to a barbiturate, but with additional PCP-like dissociative, anaesthetic and hallucinogenic effects.
Indication
Rolicyclidine has anesthetic properties and can induce a sedative effect.
Toxicity
PsychonautWikiThe long-term use of substances of the PCP class may lead to schizophrenia-like psychotic episodes, severe lasting memory loss, disorganized thinking, depression, weight loss, liver abnormalities and rhabdomyolysis (skeletal muscle breakdown). It is very strongly recommended that one use extreme caution and harm reduction practices when using this substance. For example,
Addiction & dependence
The chronic use of PCPy can be considered highly addictive with a high potential for adverse side effects such as psychosis. In comparison to other dissociatives, PCPy has been reported to be more addictive than MXE, diphenidine, ephenidine, and ketamine. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Effect Profile
CuratedStrong dissociative depth and motor impairment with mild mania, low insight
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.